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GGA1 Knockout Cell Lines

Gene: GGA1

Official Full Name: golgi associated, gamma adaptin ear containing, ARF binding protein 1provided by HGNC

Gene Summary: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28333 GGA1 Knockout cell line (HeLa) Human GGA1 1:3~1:6 Negative Online Inquiry
KO28334 GGA1 Knockout cell line (HCT 116) Human GGA1 1:2~1:4 Negative Online Inquiry
KO28335 GGA1 Knockout cell line (HEK293) Human GGA1 1:3~1:6 Negative Online Inquiry
KO28336 GGA1 Knockout cell line (A549) Human GGA1 1:3~1:4 Negative Online Inquiry

Background

GGA1 Gene Knockout Cell Lines are specifically engineered cellular models that lack the functional GGA1 gene, which encodes for the Golgi-localized, γ-ear containing ADP-ribosylation factor-binding protein 1. These cell lines are crucial for investigating the role of GGA1 in cellular processes such as protein sorting and trafficking, Golgi apparatus function, and the modulation of various signaling pathways. By disrupting the GGA1 gene, researchers can study the resulting phenotypic changes and the underlying molecular mechanisms, providing insights into cellular dysregulation associated with various diseases.

The primary function of these knockout cell lines is to facilitate the dissection of GGA1’s biological roles in pathways like endocytosis and exocytosis. The absence of GGA1 allows for detailed exploration of how disruptions in protein processing can lead to pathological states, such as neurodegeneration or cancer. Moreover, these cell lines serve as powerful tools in drug discovery and development, enabling researchers to identify potential therapeutic targets linked to GGA1-related pathways.

From a scientific perspective, the availability of GGA1 Gene Knockout Cell Lines represents a significant advancement in the study of cell biology and disease mechanisms. They offer a unique opportunity to understand the complexities of cellular behavior in a controlled manner, thereby accelerating research and yielding data that can translate into clinical applications.

Compared to alternative models, such as wild-type cell lines or other knockout systems, GGA1 Gene Knockout Cell Lines provide specificity and reliability in results due to the targeted gene disruption. This specificity reduces background noise, allowing researchers to draw clearer conclusions from experimental data.

For researchers and clinicians, these cell lines embody significant value, contributing to the advancement of knowledge in cellular biology, potential therapeutic discoveries, and the overall understanding of diseases related to GGA1 dysfunction. With a commitment to scientific excellence, our company is dedicated to providing high-quality biological products that empower researchers and enhance their ability to unlock the mysteries of cellular processes.

Please note that all services are for research use only. Not intended for any clinical use.

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