Gene: GDI1
Official Full Name: GDP dissociation inhibitor 1provided by HGNC
Gene Summary: GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37687 | GDI1 Knockout cell line (HeLa) | Human | GDI1 | 1:3~1:6 | Negative | Online Inquiry |
KO37688 | GDI1 Knockout cell line (HCT 116) | Human | GDI1 | 1:2~1:4 | Negative | Online Inquiry |
KO37689 | GDI1 Knockout cell line (HEK293) | Human | GDI1 | 1:3~1:6 | Negative | Online Inquiry |
KO37690 | GDI1 Knockout cell line (A549) | Human | GDI1 | 1:3~1:4 | Negative | Online Inquiry |
GDI1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to abrogate the expression of the GDI1 (GDP dissociation inhibitor 1) gene, a critical regulator involved in the Rho GTPase signaling pathway. By disrupting the function of this gene, these knockout cell lines provide a powerful tool for investigating the physiological and pathological roles of GDI1 in various cellular contexts. The mechanism of action involves the complete inactivation of GDI1 expression through targeted gene editing technologies, such as CRISPR-Cas9, leading to altered cellular behaviors that can be readily observed and measured.
The scientific importance of GDI1 Gene Knockout Cell Lines lies in their utility for research focused on cancer biology, neurodegenerative disorders, and cell signaling pathways. In oncology, for instance, understanding GDI1’s role in tumor cell metastasis and invasion is crucial. Furthermore, these cell lines facilitate the study of Rho GTPases, which are instrumental in cell migration and cytoskeletal dynamics. Researchers can employ these cell lines in high-throughput screening, drug discovery, and mechanistic studies, significantly advancing our understanding of cellular processes and potential therapeutic strategies.
What sets our GDI1 Gene Knockout Cell Lines apart from alternative products is their robust validation and performance in a variety of experimental setups. Each cell line is thoroughly characterized to ensure consistent and reproducible results, making them an ideal addition to any laboratory focused on cutting-edge research. Additionally, our comprehensive support and detailed product documentation empower researchers and clinicians to optimize their studies efficiently.
Investing in GDI1 Gene Knockout Cell Lines not only enhances your research capabilities but also positions you at the forefront of scientific discovery. Backed by our company's extensive expertise in gene editing and development of biological research tools, we are committed to providing high-quality products that meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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