Gene: GDF9
Official Full Name: growth differentiation factor 9provided by HGNC
Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37691 | GDF9 Knockout cell line (HEK293) | Human | GDF9 | 1:3~1:6 | Negative | Online Inquiry |
GDF9 Gene Knockout Cell Lines are advanced biological tools designed for the precise study of the Growth Differentiation Factor 9 (GDF9) gene, which plays a crucial role in ovarian function and the regulation of female fertility. These cell lines have been engineered to contain specific mutations that effectively silence the GDF9 gene, allowing researchers to elucidate the gene's impact on cellular processes, signaling pathways, and reproductive health.
The primary mechanism of these knockout cell lines involves the use of CRISPR-Cas9 technology, which introduces targeted modifications to the GDF9 gene. By observing the phenotypic and genotypic changes that occur in the absence of GDF9 expression, researchers can better understand its contributions to gametogenesis, folliculogenesis, and oocyte maturation. This is especially significant in studies related to infertility, polycystic ovary syndrome (PCOS), and other reproductive disorders, providing insights into potential therapeutic targets.
From a scientific perspective, GDF9 Gene Knockout Cell Lines hold substantial importance in both basic and applied research settings. They allow for the dissection of gene function at a cellular level and can be utilized in drug development processes aimed at improving fertility treatments. The ability to study GDF9's regulatory mechanisms in vitro paves the way for advances in reproductive technology and enhances our understanding of female reproductive biology.
One of the unique advantages of our GDF9 Gene Knockout Cell Lines is their high specificity and reliability in providing consistent results, surpassing traditional knockdown methods like RNA interference. These cell lines are also rigorously validated for their genetic alterations and phenotypic characteristics, ensuring researchers achieve reproducible and scientifically accurate data. Such precision is critical for studies requiring the manipulation of the GDF9 signaling pathways.
For researchers and clinicians focused on reproductive health and fertility treatments, the GDF9 Gene Knockout Cell Lines represent an invaluable resource. The insights gained from these studies can lead to groundbreaking discoveries and much-needed advancements in therapeutic practices. Our commitment to scientific innovation is underscored by our extensive expertise and experience in developing high-quality biological products tailored to meet the evolving needs of the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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