Gene: GDF15
Official Full Name: growth differentiation factor 15provided by HGNC
Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09284 | GDF15 Knockout cell line (HeLa) | Human | GDF15 | 1:3~1:6 | Negative | Online Inquiry |
KO09285 | GDF15 Knockout cell line (HCT 116) | Human | GDF15 | 1:2~1:4 | Negative | Online Inquiry |
KO09286 | GDF15 Knockout cell line (HEK293) | Human | GDF15 | 1:3~1:6 | Negative | Online Inquiry |
KO09287 | GDF15 Knockout cell line (A549) | Human | GDF15 | 1:3~1:4 | Negative | Online Inquiry |
GDF15 Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of growth differentiation factor 15 (GDF15), a protein implicated in various physiological and pathological processes, including inflammation, metabolic pathways, and cancer progression. These cell lines have been meticulously engineered to lack the GDF15 gene, allowing researchers to investigate the functional roles of this cytokine in a controlled environment.
The primary mechanism of GDF15 involves signaling pathways that respond to cellular stress and injury, promoting cell survival and adaptive responses. By employing gene knockout techniques, our cell lines enable scientists to explore the effects of GDF15 absence on cell behavior, gene expression, and intercellular communications, thereby elucidating its contributions to disease mechanisms or therapeutic outcomes.
In the realm of scientific research, understanding GDF15 through these specialized cell lines has significant implications for oncology, cardiology, and metabolic diseases. The knockout model allows for the exploration of drug responses and biomarkers, vital for clinical applications and therapeutic development.
Unlike traditional models, our GDF15 gene knockout cell lines provide a more precise and reliable platform for experimentation, minimizing variability associated with endogenous GDF15 levels. Their specificity and accessibility set them apart from alternative models that may not adequately represent the absence of this critical factor.
For researchers and clinicians, leveraging our GDF15 gene knockout cell lines represents an unparalleled opportunity to deepen their understanding of related pathologies and to develop innovative therapeutic strategies. Our company prides itself on its expertise in the production of high-quality biological products, ensuring that our customers receive reliable and effective research tools to advance their scientific inquiries and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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