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GCC2 Knockout Cell Lines

Gene: GCC2

Official Full Name: GRIP and coiled-coil domain containing 2provided by HGNC

Gene Summary: The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32985 GCC2 Knockout cell line (HeLa) Human GCC2 1:3~1:6 Negative Online Inquiry
KO32986 GCC2 Knockout cell line (HCT 116) Human GCC2 1:2~1:4 Negative Online Inquiry
KO32987 GCC2 Knockout cell line (HEK293) Human GCC2 1:3~1:6 Negative Online Inquiry
KO32988 GCC2 Knockout cell line (A549) Human GCC2 1:3~1:4 Negative Online Inquiry

Background

GCC2 Gene Knockout Cell Lines are genetically modified cell lines designed to provide researchers with a powerful tool for studying the functions of the GCC2 gene, a key player in cellular processes including vesicular trafficking and Golgi apparatus organization. These cell lines have undergone targeted gene editing using CRISPR-Cas9 technology, resulting in the specific knockout of the GCC2 gene to facilitate in-depth analysis of cellular mechanisms affected by its absence.

The primary function of these cell lines lies in their ability to elucidate the role of GCC2 in various biological processes, including protein sorting and cell signaling pathways. By examining the phenotypic and functional consequences of GCC2 knockout, researchers can uncover its contribution to cellular dynamics and its potential impact on diseases related to trafficking disorders. The mechanisms at play involve alterations in Golgi structure and function, which can directly affect protein maturation and delivery to the cell membrane.

In research and clinical settings, GCC2 Gene Knockout Cell Lines are invaluable for studying pathogen-host interactions, particularly in virus infection models where GCC2 has been implicated in enhancing virulence. They serve as a vital resource for drug discovery and therapeutic strategies targeting trafficking pathways. Their scientific importance is further underscored by the potential to identify novel biomarkers for diseases associated with Golgi dysfunction.

What sets GCC2 Gene Knockout Cell Lines apart from alternatives is the precision of their gene editing, ensuring a complete loss of GCC2 function without off-target effects often seen with less precise editing methods. Moreover, these cell lines are thoroughly characterized and validated for consistent performance, providing reliability that is crucial in scientific experiments.

For researchers and clinicians focused on cellular biology, these cell lines represent a significant value proposition, enabling rigorous exploration of gene functions and the development of innovative interventions. Our company prides itself on its expertise in genetic engineering and robust development of biological products, ensuring high-quality offerings that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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