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FZD6 Knockout Cell Lines

Gene: FZD6

Official Full Name: frizzled class receptor 6provided by HGNC

Gene Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11758 FZD6 Knockout cell line (HeLa) Human FZD6 1:3~1:6 Negative Online Inquiry
KO11759 FZD6 Knockout cell line (HCT 116) Human FZD6 1:2~1:4 Negative Online Inquiry
KO11760 FZD6 Knockout cell line (HEK293) Human FZD6 1:3~1:6 Negative Online Inquiry
KO11761 FZD6 Knockout cell line (A549) Human FZD6 1:3~1:4 Negative Online Inquiry

Background

FZD6 Gene Knockout Cell Lines are genetically engineered cellular models used to study the functional implications of the Frizzled 6 (FZD6) gene, a crucial component of the Wnt signaling pathway. This product allows researchers to create a precise deletion of the FZD6 gene, enabling investigations into its role in various physiological processes and diseases. The knockout mechanism is achieved through the use of CRISPR-Cas9 technology, which facilitates targeted gene editing by introducing double-strand breaks in the DNA at specific sites, leading to the inactivation of the gene.

The FZD6 gene plays a significant role in developmental biology and cell signaling, influencing processes such as cell proliferation, differentiation, and migration. Its dysregulation has been linked to various conditions, including cancer and developmental disorders. Consequently, the FZD6 Gene Knockout Cell Lines are invaluable in research settings, offering insights into gene function, the intricacies of Wnt signaling, and potential therapeutic targets in diseases associated with FZD6 aberrations.

What sets our FZD6 Gene Knockout Cell Lines apart from traditional models is their specificity and versatility. Unlike conventional cell lines, these knockout lines provide researchers with a homogenous population of cells lacking the FZD6 gene, ensuring more reliable and reproducible results. Additionally, our cell lines are meticulously characterized and validated, offering confidence in their application for both basic research and preclinical studies.

For researchers and clinicians focused on unraveling the complexities of the Wnt pathway or exploring innovative therapies for related diseases, FZD6 Gene Knockout Cell Lines represent a powerful tool. Their application can lead to a deeper understanding of molecular mechanisms, ultimately paving the way for novel therapeutic approaches.

With a strong background in genetic engineering and cell biology, our company specializes in developing high-quality biological products. We are committed to providing researchers with the tools they need to advance their investigations, enhancing the potential for breakthroughs in medical science.

Please note that all services are for research use only. Not intended for any clinical use.

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