Gene: FURIN
Official Full Name: furin, paired basic amino acid cleaving enzymeprovided by HGNC
Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00938 | FURIN Knockout cell line(HeLa) | Human | FURIN | 1:3~1:6 | Negative | Online Inquiry |
KO17523 | FURIN Knockout cell line (HCT 116) | Human | FURIN | 1:2~1:4 | Negative | Online Inquiry |
KO17524 | FURIN Knockout cell line (HEK293) | Human | FURIN | 1:3~1:6 | Negative | Online Inquiry |
KO17525 | FURIN Knockout cell line (A549) | Human | FURIN | 1:3~1:4 | Negative | Online Inquiry |
FURIN Gene Knockout Cell Lines are specialized cellular models generated through precise genetic engineering techniques aimed at disrupting the FURIN gene, which encodes a key proprotein convertase enzyme involved in the activation of various protein substrates, including growth factors and viral proteins. These cell lines serve as essential tools for elucidating the functions and pathways associated with FURIN and its critical role in cellular processes such as proliferation, differentiation, and viral entry.
The primary mechanism through which FURIN Gene Knockout Cell Lines operate is the abrogation of FURIN activity, leading to the uncontrolled accumulation of its unprocessed substrates. This characteristic allows researchers to study the downstream effects involved in developmental biology and pathogenesis, particularly in conditions such as cancer and infectious diseases. By using these knockout cell lines, scientists can further explore the roles FURIN plays in mediating the virulence of pathogenic viruses such as SARS-CoV-2, expanding our understanding of viral entry and infection pathways.
From a scientific perspective, FURIN Gene Knockout Cell Lines are invaluable in both basic and applied research. They facilitate the investigation of therapeutic targets, drug screening, and the development of novel intervention strategies. By creating an experimental model that simulates specific disease mechanisms, these cell lines enhance the reproducibility and reliability of research outcomes.
The advantages of FURIN Gene Knockout Cell Lines over traditional models include their high specificity, the precise genetic alterations that remove confounding variables and the ability to generate consistent, reproducible results across experiments. Compared to alternatives such as pharmacological inhibitors, these cell lines provide a more controllable and deeper understanding of the consequences of FURIN loss.
For researchers and clinicians alike, the ability to manipulate and study FURIN in a controlled cellular environment opens new avenues for discovery and innovation, making it a crucial addition to any biological research toolkit. At [Your Company Name], we pride ourselves on our dedication to providing top-tier biological products, harnessing advanced genetic technologies to support the scientific community in their quest for knowledge and therapeutic breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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