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FRAS1 Knockout Cell Lines

Gene: FRAS1

Official Full Name: Fraser extracellular matrix complex subunit 1provided by HGNC

Gene Summary: This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26212 FRAS1 Knockout cell line (HeLa) Human FRAS1 1:3~1:6 Negative Online Inquiry
KO26213 FRAS1 Knockout cell line (HCT 116) Human FRAS1 1:2~1:4 Negative Online Inquiry
KO26214 FRAS1 Knockout cell line (HEK293) Human FRAS1 1:3~1:6 Negative Online Inquiry
KO26215 FRAS1 Knockout cell line (A549) Human FRAS1 1:3~1:4 Negative Online Inquiry

Background

FRAS1 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the function of the FRAS1 gene, which plays a crucial role in the formation of extracellular matrix (ECM) and connective tissues. These cell lines are created through precise gene-editing techniques, such as CRISPR-Cas9, which introduce targeted deletions in the FRAS1 gene, enabling researchers to investigate its role in cellular processes and disease mechanisms.

The primary function of the FRAS1 Gene Knockout Cell Lines is to serve as a powerful tool for elucidating the biological pathways associated with FRAS1, particularly in relation to disorders affecting connective tissues, such as Fraser syndrome. By observing the phenotypic and molecular changes in these knockout cells, researchers can gain insight into how the absence of FRAS1 influences cellular behavior, ECM composition, and the signaling pathways that govern tissue integrity and repair.

The scientific importance of these cell lines extends to their applications in both basic research and clinical settings. They can be used to model diseases linked to ECM dysregulation, thus paving the way for the development of targeted therapies and innovative treatment strategies. Furthermore, these cell lines provide a platform for high-throughput drug screening and genetic studies aimed at identifying new therapeutic targets.

Key advantages of FRAS1 Gene Knockout Cell Lines include their high specificity and reproducibility, as well as their ability to be easily integrated into existing laboratory workflows. Compared to alternative models, such as conventional knockout mice or other cell lines, these human-derived knockout cell lines offer a closer approximation to human biology, allowing for more relevant and translatable research outcomes.

For researchers and clinicians, the value of FRAS1 Gene Knockout Cell Lines lies in their capacity to bridge the gap between fundamental biology and clinical application. By enabling the exploration of FRAS1-related pathologies, these cell lines hold promise for advancing our understanding of connective tissue disorders and developing novel therapeutic interventions.

Our company is dedicated to providing high-quality, precision-engineered biological products designed to facilitate groundbreaking research. With extensive expertise in gene editing and cell line development, we are committed to delivering innovative solutions that support the scientific community in their quest to unlock the mysteries of human health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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