Gene: FMOD
Official Full Name: fibromodulinprovided by HGNC
Gene Summary: Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00610 | FMOD gRNA3-gRNA4 KO plasmid | FMOD | $850 | |||
KO11555 | FMOD Knockout cell line (HeLa) | Human | FMOD | 1:3~1:6 | Negative | Online Inquiry |
FMOD Gene Knockout Cell Lines are genetically modified cellular models specifically designed to study the role of the FMOD gene, which encodes the protein fibromodulin. These cell lines have been engineered using CRISPR-Cas9 technology to create targeted gene disruptions, allowing researchers to investigate the effects of FMOD loss in various biological processes, particularly those related to extracellular matrix remodeling and cellular signaling.
The primary mechanism of FMOD function involves its role as a key regulator in collagen assembly and matrix organization, which is crucial for maintaining tissue integrity and function. By utilizing these knockout cell lines, researchers can explore the contributions of FMOD to pathological conditions such as fibrosis, cancer, and cardiovascular diseases. The absence of FMOD can alter cellular responses to stimuli, leading to significant changes in cell behavior, making these cell lines invaluable for mechanistic studies.
In addition to their potential applications in basic research, FMOD Gene Knockout Cell Lines are of great interest in drug development and pharmaceutical research, allowing for the assessment of new therapeutic agents targeting pathways influenced by FMOD. The unique advantage of these cell lines lies in their specificity and ability to provide insights that traditional models may not, such as understanding the direct consequences of gene loss on cellular function and associated disease states.
Researchers and clinicians alike will find these cell lines indispensable for elucidating FMOD's role in health and disease, driving innovative solutions in therapeutic strategies. Our company has extensive expertise in genetic engineering and cellular biology, ensuring a product that meets rigorous scientific standards, is easy to work with, and supports groundbreaking research in the field. We are committed to empowering scientific discovery with reliable and precise biological tools.
Please note that all services are for research use only. Not intended for any clinical use.
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