Gene: FGD1
Official Full Name: FYVE, RhoGEF and PH domain containing 1provided by HGNC
Gene Summary: This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37892 | FGD1 Knockout cell line (HeLa) | Human | FGD1 | 1:3~1:6 | Negative | Online Inquiry |
KO37893 | FGD1 Knockout cell line (HCT 116) | Human | FGD1 | 1:2~1:4 | Negative | Online Inquiry |
KO37894 | FGD1 Knockout cell line (HEK293) | Human | FGD1 | 1:3~1:6 | Negative | Online Inquiry |
KO37895 | FGD1 Knockout cell line (A549) | Human | FGD1 | 1:3~1:4 | Negative | Online Inquiry |
FGD1 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically remove or "knock out" the FGD1 gene, thereby enabling researchers to study the role of this gene in cellular processes and disease mechanisms. The FGD1 gene is crucial in regulating actin cytoskeleton dynamics, and its mutations are implicated in various pathologies, including developmental anomalies and cardiovascular diseases. By utilizing CRISPR-Cas9 gene-editing technology, these cell lines allow for precise gene disruptions, enabling the investigation of gene function and the discovery of novel therapeutic targets.
The primary function of the FGD1 Gene Knockout Cell Lines involves the disruption of normal gene expression and its downstream signaling pathways, offering insights into cellular responses under FGD1 deficiency. Researchers can observe alterations in phenotypic characteristics, including changes in cell morphology, proliferation, and motility, facilitating a comprehensive understanding of the gene's roles in pathophysiology. Such insights are invaluable in both basic and translational research settings, where elucidating the mechanisms underlying diseases can lead to the development of targeted therapies.
One of the significant advantages of using FGD1 Gene Knockout Cell Lines is their specificity and versatility compared to traditional gene silencing methods, such as RNA interference. These knockout models provide a complete loss-of-function analysis rather than a partial reduction, yielding more reliable data. Moreover, they can be integrated into various experimental setups, including drug screening, genetic interaction studies, and the assessment of cellular responses to environmental stimuli.
For researchers and clinicians, these cell lines represent a powerful tool in advancing our understanding of the FGD1 gene's role in human health. The ability to dissect disease mechanisms at a cellular level accelerates the pathway toward clinical applications, particularly in identifying novel biomarkers and therapeutic strategies for diseases linked to FGD1 dysfunction.
Our company specializes in cutting-edge genetic engineering technologies and has a proven track record in providing high-quality biological products. The FGD1 Gene Knockout Cell Lines are a testament to our commitment to supporting the scientific community's quest for breakthroughs in genetics and molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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