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FCGRT Knockout Cell Lines

Gene: FCGRT

Official Full Name: Fc gamma receptor and transporterprovided by HGNC

Gene Summary: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37907 FCGRT Knockout cell line (HeLa) Human FCGRT 1:3~1:6 Negative Online Inquiry
KO37908 FCGRT Knockout cell line (HEK293) Human FCGRT 1:3~1:6 Negative Online Inquiry
KO37909 FCGRT Knockout cell line (A549) Human FCGRT 1:3~1:4 Negative Online Inquiry

Background

FCGRT Gene Knockout Cell Lines are engineered cellular models that specifically disable the Fc gamma receptor transporter (FCGRT) gene, a crucial component in the immune response responsible for antibody binding and transport. Through the use of advanced CRISPR/Cas9 gene-editing technology, these cell lines are meticulously constructed to facilitate the study of Fc-mediated immune processes, including the handling of immunoglobulins and the development of therapeutic antibodies.

The primary function of FCGRT is to mediate the transport of IgG antibodies across cellular barriers, ensuring proper immune function. By providing a knockout model, researchers can investigate the implications of FCGRT deficiency on immune responses, drug efficacy, and antibody-mediated diseases. This genetic alteration allows for in-depth analysis of the pathways and mechanisms involved in disease progression, making these cell lines invaluable tools in both basic and applied biomedical research.

The scientific importance of FCGRT Gene Knockout Cell Lines extends to various areas, including immunology, pharmacology, and translational medicine. In clinical settings, these models facilitate the development of novel therapies by elucidating Fc receptor interactions and their impact on therapeutic antibody delivery and action. Unlike traditional cell lines, these knockout models offer a more precise assessment of the FCGRT gene's role, enhancing experimental reproducibility and accuracy.

Moreover, the unique selling points of our FCGRT Gene Knockout Cell Lines lie in their high specificity and customization potential. Our lines are fully characterized, ensuring consistent performance, which is critical for experimental integrity. They allow researchers to quickly identify the effects of FCGRT deficiency in various biological contexts without the confounding variances often encountered in wild-type cell lines.

For researchers and clinicians alike, the value of our FCGRT Gene Knockout Cell Lines lies in their ability to transform basic research into actionable insights, ultimately contributing to the development of therapeutic strategies against a wide spectrum of diseases. Our commitment to providing high-quality, reliable scientific products is backed by years of expertise and a dedication to advancing biotechnological research and applications.

Please note that all services are for research use only. Not intended for any clinical use.

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