Gene: FBXO22
Official Full Name: F-box protein 22provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05014 | FBXO22 Knockout cell line (HeLa) | Human | FBXO22 | 1:3~1:6 | Negative | Online Inquiry |
KO05015 | FBXO22 Knockout cell line (HCT 116) | Human | FBXO22 | 1:2~1:4 | Negative | Online Inquiry |
KO05016 | FBXO22 Knockout cell line (HEK293) | Human | FBXO22 | 1:3~1:6 | Negative | Online Inquiry |
KO05017 | FBXO22 Knockout cell line (A549) | Human | FBXO22 | 1:3~1:4 | Negative | Online Inquiry |
FBXO22 Gene Knockout Cell Lines represent a cutting-edge biological tool designed for researchers investigating the functional role of the FBXO22 gene in various cellular processes. These genetically modified cell lines are derived through advanced CRISPR/Cas9 technology, which facilitates the precise alteration of the FBXO22 gene to create a knockout model. By completely disabling FBXO22 expression, these cell lines enable scientists to study the downstream effects of its absence at the molecular, cellular, and organismal levels.
The key function of FBXO22 is associated with the regulation of protein degradation through the ubiquitin-proteasome pathway. This suggests that the gene plays a critical role in maintaining protein homeostasis, influencing cellular responses to stress, proliferation, and apoptosis. Hence, using these knockout cell lines, researchers can explore the implications of FBXO22 in diseases characterized by dysregulation of protein turnover, such as cancer and neurodegenerative disorders. This knowledge is crucial for developing targeted therapeutic strategies.
The scientific importance of FBXO22 Gene Knockout Cell Lines extends into both basic and clinical research settings. They serve as invaluable models for drug discovery, allowing for the screening of compounds that may selectively target cells with altered FBXO22 function. Furthermore, these models can provide insights into pathophysiological mechanisms underlying various diseases, aiding in the identification of novel biomarkers for early diagnosis or prognosis.
What sets our FBXO22 Gene Knockout Cell Lines apart from alternative products is their robust validation for gene editing effectiveness, along with a comprehensive catalog of supporting data confirming the reliability and reproducibility of experimental outcomes. Researchers can trust these models due to our rigorous quality control measures and a commitment to maintaining genetic integrity throughout the cell line development process.
Overall, FBXO22 Gene Knockout Cell Lines offer exceptional value to researchers and clinicians alike by facilitating a deeper understanding of gene function and the molecular mechanisms of disease. By leveraging state-of-the-art gene editing techniques and providing extensive support resources, our company stands at the forefront of advancing biological research products, ensuring that scientists have access to the tools necessary for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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