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FBXO21 Knockout Cell Lines

Gene: FBXO21

Official Full Name: F-box protein 21provided by HGNC

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04390 FBXO21 Knockout cell line (HeLa) Human FBXO21 1:3~1:6 Negative Online Inquiry
KO04391 FBXO21 Knockout cell line (HCT 116) Human FBXO21 1:2~1:4 Negative Online Inquiry
KO04392 FBXO21 Knockout cell line (HEK293) Human FBXO21 1:3~1:6 Negative Online Inquiry
KO04393 FBXO21 Knockout cell line (A549) Human FBXO21 1:3~1:4 Negative Online Inquiry

Background

FBXO21 Gene Knockout Cell Lines represent a pioneering advancement in genetic research, designed to facilitate the investigation into the physiological roles and mechanisms of the FBXO21 gene. These genetically engineered cell lines are generated through CRISPR/Cas9 technology, resulting in a complete knockout of the FBXO21 gene, which is implicated in various processes including protein degradation, cell signaling, and immune responses. By disrupting this gene, researchers can elucidate its contributions to cellular behavior, disease models, and therapeutic responses.

The key function of FBXO21 Gene Knockout Cell Lines lies in their ability to serve as a controlled system for studying the absence of FBXO21 protein and its downstream effects. By comparing knockout cells to wild-type cells, scientists can identify alterations in pathways such as the ubiquitin-proteasome system, which is crucial for maintaining cellular homeostasis. This model has significant implications for understanding cancer biology, autoimmune diseases, and other pathologies where FBXO21 is thought to play a pivotal role.

In research and clinical settings, FBXO21 knockout models are invaluable for drug discovery and development, allowing researchers to screen for compounds that might target pathways affected by the absence of FBXO21. The versatility of these cell lines also extends to applications in gene therapy, synthetic biology, and biomarker discovery, broadening their relevance across multiple fields of study.

What sets FBXO21 Gene Knockout Cell Lines apart from existing alternatives is their high specificity and efficiency, as well as the reproducibility of results. Unlike other knockouts that may exhibit partial inhibition or off-target effects, these cell lines provide a reliable platform for researchers aiming to achieve definitive insights into gene function without the confounding variables often present in less precise methodologies.

For researchers, clinicians, and biotechnology companies aiming for robust and actionable data, FBXO21 Gene Knockout Cell Lines offer a critical tool that enhances experimental rigor and accelerates the pace of discovery. Our company's commitment to excellence in genetic engineering and precision cell line development ensures that users receive high-quality products backed by extensive validation and support, empowering them to tackle the complexities of genetic research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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