Gene: FBXL13
Official Full Name: F-box and leucine rich repeat protein 13provided by HGNC
Gene Summary: Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27141 | FBXL13 Knockout cell line (HeLa) | Human | FBXL13 | 1:3~1:6 | Negative | Online Inquiry |
FBXL13 Gene Knockout Cell Lines are genetically modified cell lines in which the FBXL13 gene has been inactivated through targeted gene knockout techniques, such as CRISPR/Cas9 or homologous recombination. FBXL13 encodes an E3 ubiquitin ligase involved in various cellular processes, including protein degradation, cell cycle regulation, and signal transduction pathways. By knocking out this gene, researchers can investigate the cellular functions and molecular pathways that rely on FBXL13, providing critical insights into its role in human diseases, such as cancer and neurodegenerative disorders.
The key mechanism behind FBXL13 Gene Knockout Cell Lines lies in their ability to facilitate loss-of-function studies. These cell lines allow researchers to observe phenotypic changes, alter biochemical pathways, and assess downstream effects of signaling cascades when the FBXL13 gene is nonfunctional. This, in turn, is pivotal for elucidating the gene's involvement in critical biological processes and disease pathology.
The scientific importance of FBXL13 Gene Knockout Cell Lines extends into both basic research and clinical applications. They serve as valuable models for drug discovery, enabling the identification of potential therapeutic targets and the evaluation of drug efficacy. In cancer research, these cell lines help in understanding tumor biology and gene interactions, paving the way for personalized medicine approaches.
What sets FBXL13 Gene Knockout Cell Lines apart from alternative models is their specific targeting and validation, which ensures precise modification of the gene with minimal off-target effects. This specificity enhances the reliability of experimental outcomes, making them a preferred choice for researchers focused on translational studies.
Researchers and clinicians alike will find great value in utilizing FBXL13 Gene Knockout Cell Lines, as they encompass a robust tool for driving discoveries in gene function, disease mechanisms, and drug development. By equipping scientists with these knockout models, they enable a deeper understanding of complex biological systems and facilitate the advancement of therapeutic strategies.
At our company, we bring extensive expertise in developing innovative genetic tools and cell line models, supporting the research community in uncovering the complexities of gene functions and their implications in health and disease. We're committed to advancing scientific understanding through high-quality biological products.
Please note that all services are for research use only. Not intended for any clinical use.
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