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FBLIM1 Knockout Cell Lines

Gene: FBLIM1

Official Full Name: filamin binding LIM protein 1provided by HGNC

Gene Summary: This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17689 FBLIM1 Knockout cell line (HeLa) Human FBLIM1 1:3~1:6 Negative Online Inquiry
KO17690 FBLIM1 Knockout cell line (HCT 116) Human FBLIM1 1:2~1:4 Negative Online Inquiry
KO17691 FBLIM1 Knockout cell line (HEK293) Human FBLIM1 1:3~1:6 Negative Online Inquiry
KO17692 FBLIM1 Knockout cell line (A549) Human FBLIM1 1:3~1:4 Negative Online Inquiry

Background

FBLIM1 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to eliminate the expression of the FBLIM1 gene, which encodes an important protein involved in various cellular processes, including cell adhesion, proliferation, and mechanotransduction. These cell lines are critical tools for researchers investigating the role of FBLIM1 in developmental biology, cancer progression, and other diseases.

The primary function of FBLIM1 Gene Knockout Cell Lines is to provide a model in which the effects of the absence of the FBLIM1 protein can be studied. The knockout is achieved through advanced gene-editing techniques such as CRISPR/Cas9, which directs precision cuts in the DNA sequence at the target locus, effectively disrupting the gene. This enables scientists to explore cellular phenotypes, signaling pathways, and functional disruptions that occur in the absence of FBLIM1, thereby enhancing our understanding of its biological significance.

In research and clinical settings, these cell lines are invaluable for elucidating the pathways and mechanisms influenced by FBLIM1, offering insights into potential therapeutic targets for various diseases, including fibrotic diseases and certain cancers. By facilitating detailed studies on gene function, they support the development of novel treatment strategies and contribute to personalized medicine approaches.

What sets FBLIM1 Gene Knockout Cell Lines apart from other gene knockout models is their validated efficacy and reliability, as backed by rigorous testing and comprehensive data. They come with user-friendly protocols and are compatible with various assay formats, providing flexibility for diverse experimental designs.

For researchers and clinicians, investing in FBLIM1 Gene Knockout Cell Lines unlocks the potential for groundbreaking discoveries that can lead to enhanced diagnostic and therapeutic solutions. The ability to study gene function in a controlled environment accelerates the path from basic research to clinical application.

Our company specializes in the development of high-quality biological products and consistently delivers accurately engineered cell lines that empower the scientific community to advance research. With a commitment to innovation and excellence, we are dedicated to supporting your research endeavors with our exceptional offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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