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F3 Knockout Cell Lines

Gene: F3

Official Full Name: coagulation factor III, tissue factorprovided by MGI

Gene Summary: This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00653 F3 gRNA5-gRNA6 KO plasmid F3 $850
KO01193 F3 Knockout cell line(B16-F10) Mouse F3 1:3~1:4 Negative Online Inquiry
KO17849 F3 Knockout cell line (HeLa) Human F3 1:3~1:6 Negative Online Inquiry
KO17850 F3 Knockout cell line (HCT 116) Human F3 1:2~1:4 Negative Online Inquiry
KO17851 F3 Knockout cell line (HEK293) Human F3 1:3~1:6 Negative Online Inquiry
KO17852 F3 Knockout cell line (A549) Human F3 1:3~1:4 Negative Online Inquiry

Background

F3 Gene Knockout Cell Lines are specifically designed cellular models that facilitate the study of the F3 gene's role in various biological processes. These cell lines have been genetically modified to completely eliminate the expression of the F3 gene, allowing researchers to observe the phenotypic consequences of its absence on cellular behavior, signaling pathways, and interactions.

The primary function of F3 Gene Knockout Cell Lines is to provide a platform for functional genomics research, enabling scientists to dissect the cellular mechanisms mediated by the F3 protein. By employing techniques such as CRISPR-Cas9 gene editing, these knockout cell lines offer a precise and efficient method for studying gene function. Researchers can utilize these models to investigate the implications of F3 in areas such as coagulation, cell adhesion, and wound healing, thus shedding light on its potential role in various diseases, including cancer and thrombosis.

The scientific significance of F3 Gene Knockout Cell Lines extends into both research and clinical applications. In research settings, they are invaluable for exploring biomarkers, drug targets, and disease mechanisms. Clinically, such models contribute to the development of personalized medicine strategies, enabling targeted therapies based on the unique genetic profiles of patients.

What distinguishes F3 Gene Knockout Cell Lines from alternatives is their high specificity, low off-target effects, and robust reproducibility, which facilitate reliable experimental outcomes. Moreover, these cell lines offer researchers a ready-to-use solution that accelerates experimental timelines, reducing the time and resources typically required for generating custom knockout models.

For researchers and clinicians alike, the availability of F3 Gene Knockout Cell Lines can dramatically enhance the capacity for groundbreaking discoveries and therapeutic innovations in the field of molecular biology. Our company specializes in producing high-quality biological products, leveraging cutting-edge technologies and a commitment to excellence to ensure that you receive reliable tools that empower your research and clinical endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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