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EPHA10 Knockout Cell Lines

Gene: EPHA10

Official Full Name: EPH receptor A10provided by HGNC

Gene Summary: Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17944 EPHA10 Knockout cell line (HCT 116) Human EPHA10 1:2~1:4 Negative Online Inquiry
KO17945 EPHA10 Knockout cell line (HEK293) Human EPHA10 1:3~1:6 Negative Online Inquiry

Background

EPHA10 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the expression of the EPHA10 gene, a member of the Eph receptor family that plays a crucial role in various cellular processes, including adhesion, migration, and differentiation. These knockout cell lines serve as pivotal tools in both basic and applied biological research, enabling investigators to elucidate the functional roles of EPHA10 in cellular signaling pathways and its implications in disease mechanisms.

The primary function of EPHA10 Gene Knockout Cell Lines lies in their ability to facilitate loss-of-function studies, allowing scientists to observe the effects of EPHA10 absence on cell behavior, gene expression, and interaction with neighboring cells. The knockout is achieved through targeted genome editing techniques, such as CRISPR-Cas9, which ensure precise modifications that enhance the reliability of experimental outcomes. This specificity allows researchers to analyze how perturbations in EPHA10 expression can influence pathological conditions, particularly in cancer biology and neurodevelopmental disorders.

The scientific significance of employing EPHA10 knockout models extends beyond fundamental research. In clinical settings, these cell lines can serve as platforms for drug discovery and development, helping to identify potential therapeutic targets and biomarkers. By validating the role of EPHA10 in specific disease contexts, researchers can facilitate the translation of findings from bench to bedside.

What sets our EPHA10 Gene Knockout Cell Lines apart from alternative products is their comprehensive validation and characterization. Each cell line is rigorously tested for gene disruption efficiency, expression profiles, and phenotypic alterations, ensuring optimal performance and reproducibility for experimental applications. This guarantees that researchers can obtain meaningful and consistent results, mitigating variability commonly encountered in experimental designs.

For researchers and clinicians seeking precise and effective tools for gene function analysis, the EPHA10 Gene Knockout Cell Lines present an invaluable resource. By harnessing the power of these knockout models, users can deepen their understanding of EPHA10's role in health and disease, ultimately supporting advancements in therapeutic development.

Our company combines extensive experience in genetic engineering with a commitment to quality and innovation, providing reliable biological products designed to meet the evolving needs of the scientific community. We understand the critical nature of your research, and we are dedicated to supporting your discoveries with our expertly crafted products.

Please note that all services are for research use only. Not intended for any clinical use.

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