Gene: EPHA1
Official Full Name: EPH receptor A1provided by HGNC
Gene Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38026 | EPHA1 Knockout cell line (HeLa) | Human | EPHA1 | 1:3~1:6 | Negative | Online Inquiry |
KO38027 | EPHA1 Knockout cell line (HCT 116) | Human | EPHA1 | 1:2~1:4 | Negative | Online Inquiry |
EPHA1 Gene Knockout Cell Lines are specialized cellular models wherein the EPHA1 gene has been deliberately inactivated. This gene, part of the Ephrin receptor family, plays a critical role in cell signaling pathways that govern various biological processes, including neural development and tissue homeostasis. By utilizing these knockout cell lines, researchers can elucidate the specific functions of EPHA1 without the confounding effects of its normal biological activity, thereby generating insights into its role in disease mechanisms such as cancer progression and neurodegenerative disorders.
The key function of EPHA1 gene knockout is primarily centered on the analysis of cellular behavior and interaction, particularly in response to external growth factors or in the context of cellular adhesion. The absence of EPHA1 alters downstream signaling pathways, which can be assessed through various assays that measure cell proliferation, migration, and attachment. These mechanistic insights are invaluable for studying pathologies where EPHA1 signaling is implicated, allowing for the development of targeted therapeutic strategies.
The scientific importance of these knockout cell lines extends into both basic research and clinical applications. In lab settings, they serve as essential tools for understanding cellular dynamics in health and disease, while in translational research, they contribute to the identification of potential drug targets and the development of new therapeutic agents.
What sets EPHA1 Gene Knockout Cell Lines apart from other genetic models is their high specificity and reliability, allowing for reproducible results in experiments aimed at dissecting complex biological interactions. Furthermore, their availability in various cellular backgrounds enhances their versatility, making them suitable for a broad array of research applications.
For researchers and clinicians, the value of these cell lines lies in their ability to provide a clear view of the cellular role of EPHA1, ensuring more effective and informed approaches to interventions. With a commitment to innovation and quality, our company has established itself as a leader in the provision of genomic models, ensuring that scientists can advance their research with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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