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EPG5 Knockout Cell Lines

Gene: EPG5

Official Full Name: ectopic P-granules 5 autophagy tethering factorprovided by HGNC

Gene Summary: This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17946 EPG5 Knockout cell line (HeLa) Human EPG5 1:3~1:6 Negative Online Inquiry
KO17947 EPG5 Knockout cell line (HCT 116) Human EPG5 1:2~1:4 Negative Online Inquiry
KO17948 EPG5 Knockout cell line (HEK293) Human EPG5 1:3~1:6 Negative Online Inquiry
KO17949 EPG5 Knockout cell line (A549) Human EPG5 1:3~1:4 Negative Online Inquiry

Background

EPG5 Gene Knockout Cell Lines are a unique resource designed for researchers aiming to investigate the biological roles of the EPG5 gene, which is pivotal in regulating autophagy and endosomal processes. By employing CRISPR-Cas9 technology, these cell lines exhibit a complete knockout of the EPG5 gene, facilitating the study of its crucial functions in cellular homeostasis, immune responses, and neurological processes.

The primary function of EPG5 involves the regulation of endosomal trafficking and the autophagic pathway, impacting the health of organelles and overall cellular organization. By utilizing these knockout cell lines, researchers can elucidate the downstream effects of EPG5 absence, such as alterations in cellular signaling pathways, changes in protein aggregation, and impacts on immune competency. This makes EPG5 knockout cell lines an invaluable tool for dissecting the complexities of autophagy-related diseases, including neurodegenerative disorders and cancer.

In scientific research and clinical studies, the ability to target specific genes enhances the precision of experimental designs, allowing for robust validation of hypotheses regarding disease mechanisms. Compared to alternative methods, such as RNAi or pharmacological inhibitors, EPG5 Gene Knockout Cell Lines provide a stable and consistent model that eliminates potential off-target effects and enables long-term studies of gene function.

Markedly, the unique selling points of our EPG5 Gene Knockout Cell Lines include their validated genetic modification, optimal growth conditions, and comprehensive support packages for experimental design. These attributes not only streamline the research process but also enhance reproducibility and reliability, making our cell lines a smart choice for researchers and clinicians aiming to push the boundaries in molecular biology and therapeutic development.

As a company renowned for its commitment to excellence in cellular products, we are dedicated to providing top-quality biological tools, ensuring researchers have everything needed to advance their studies effectively and efficiently.

Please note that all services are for research use only. Not intended for any clinical use.

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