Gene: ELK4
Official Full Name: ETS transcription factor ELK4provided by HGNC
Gene Summary: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10820 | ELK4 Knockout cell line (HeLa) | Human | ELK4 | 1:3~1:6 | Negative | Online Inquiry |
KO10821 | ELK4 Knockout cell line (HCT 116) | Human | ELK4 | 1:2~1:4 | Negative | Online Inquiry |
KO10822 | ELK4 Knockout cell line (HEK293) | Human | ELK4 | 1:3~1:6 | Negative | Online Inquiry |
KO10823 | ELK4 Knockout cell line (A549) | Human | ELK4 | 1:3~1:4 | Negative | Online Inquiry |
ELK4 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology and genetic research, specifically designed to facilitate the study of the ELK4 gene's function and its role in various cellular processes. These engineered cell lines have undergone precise genetic modification to inactivate the ELK4 gene, a member of the ETS family of transcription factors known for its critical involvement in cellular growth, differentiation, and apoptosis.
The key function of the ELK4 Gene Knockout Cell Lines lies in their ability to provide a unique platform for researchers to investigate the consequences of ELK4 disruption within a controlled environment. By observing the phenotypic and molecular changes that occur upon ELK4 knockout, scientists can elucidate the gene’s contribution to critical biological pathways, contributing to a deeper understanding of its role in oncogenesis and other diseases. The mechanisms through which these cell lines operate include altered signaling cascades and shifts in gene expression profiles that can be quantified using various molecular biology techniques, such as qPCR, Western blotting, and RNA sequencing.
The scientific importance of these cell lines is underscored by their applications in both basic research and clinical settings. Studies utilizing ELK4 knockout models have the potential to uncover novel therapeutic targets for cancers where ELK4 is implicated, as well as inform strategies for regenerative medicine. Furthermore, these cell lines offer a distinct advantage by providing reproducible and reliable results that can enhance the validity of research findings and aid in the development of targeted therapies.
Compared to alternative models, such as transient knockdown systems or wild-type cell lines, the ELK4 Gene Knockout Cell Lines allow for more stable, long-term expression studies, offering a clearer depiction of gene function over time. This stability is crucial for researchers seeking to explore the complex interactions influenced by ELK4 without the confounding variables introduced by transient manipulations.
In conclusion, ELK4 Gene Knockout Cell Lines are invaluable resources for researchers and clinicians aiming to advance our understanding of gene function in disease pathology. Our company prides itself on its expertise in developing high-quality, genetically modified cell lines tailored for innovative research applications. By choosing our ELK4 Gene Knockout Cell Lines, you invest in a powerful tool that equips you to pioneer new discoveries and unlock the mysteries of gene regulation.
Please note that all services are for research use only. Not intended for any clinical use.
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