Home / EFNA3 Knockout Cell Lines

EFNA3 Knockout Cell Lines

Gene: EFNA3

Official Full Name: ephrin A3provided by HGNC

Gene Summary: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09056 EFNA3 Knockout cell line (HeLa) Human EFNA3 1:3~1:6 Negative Online Inquiry
KO09057 EFNA3 Knockout cell line (HCT 116) Human EFNA3 1:2~1:4 Negative Online Inquiry
KO09058 EFNA3 Knockout cell line (HEK293) Human EFNA3 1:3~1:6 Negative Online Inquiry
KO09059 EFNA3 Knockout cell line (A549) Human EFNA3 1:3~1:4 Negative Online Inquiry

Background

EFNA3 Gene Knockout Cell Lines represent a groundbreaking tool in the field of molecular biology, specifically designed for the functional analysis of the Ephrin-A3 (EFNA3) gene. These custom-engineered cell lines are created using CRISPR-Cas9 technology to achieve targeted gene disruption, allowing researchers to investigate the roles of EFNA3 in various biological processes such as cell signaling, migration, and oncogenesis. The knockout of the EFNA3 gene enables a clearer understanding of its contributions to disease mechanisms, particularly in cancers where aberrant Ephrin signaling is implicated.

The primary mechanism behind these cell lines involves the precise targeting and excision of the EFNA3 gene, resulting in the absence of functional protein expression. This not only facilitates detailed studies on the downstream signaling pathways modulated by EFNA3 but also allows for the evaluation of potential therapeutic targets within these pathways. Through loss-of-function analyses, researchers can discover how EFNA3 influences cellular behaviors under both normal and pathological conditions.

The scientific importance of EFNA3 Gene Knockout Cell Lines is reflected in their vast applications in research and clinical settings. They serve as essential tools for uncovering the complexities of cell communication and tissue interaction, paving the way for novel drug discovery and personalized medicine approaches. Studies utilizing these knockout lines can lead to significant advancements in our understanding of EFNA3's role in tumor progression and metastasis, thereby influencing therapeutic strategies against malignancies.

Compared to other genetic tools, the specificity and efficiency of CRISPR-Cas9 mean that researchers benefit from a high degree of precision without the off-target effects common with earlier methods. This results in more reliable data and accelerated research timelines, enhancing the value of findings derived from EFNA3 Gene Knockout Cell Lines.

For researchers and clinicians, the ability to manipulate EFNA3 function opens new avenues for investigation and ultimately contributes to the quest for targeted therapies. Our company, with its commitment to providing high-quality biological tools and resources, combines expertise in gene editing with an understanding of the needs within the scientific community. The innovation represented by EFNA3 Gene Knockout Cell Lines exemplifies our dedication to advancing biomedical research and improving patient outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.