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DPYSL2 Knockout Cell Lines

Gene: DPYSL2

Official Full Name: dihydropyrimidinase like 2provided by HGNC

Gene Summary: This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03814 DPYSL2 Knockout cell line (HeLa) Human DPYSL2 1:3~1:6 Negative Online Inquiry
KO03815 DPYSL2 Knockout cell line (HCT 116) Human DPYSL2 1:2~1:4 Negative Online Inquiry
KO03816 DPYSL2 Knockout cell line (HEK293) Human DPYSL2 1:3~1:6 Negative Online Inquiry
KO03817 DPYSL2 Knockout cell line (A549) Human DPYSL2 1:3~1:4 Negative Online Inquiry

Background

DPYSL2 Gene Knockout Cell Lines represent a groundbreaking resource in molecular biology, providing a unique platform for studying the physiological and pathological roles of the DPYSL2 gene in diverse cellular contexts. This product consists of human cell lines that have been genetically modified to contain disruptions in the DPYSL2 gene, a gene known for its involvement in neuronal development and synaptic plasticity.

The key functionality of DPYSL2 Gene Knockout Cell Lines lies in their ability to facilitate the examination of gene function and its associated signaling pathways. By utilizing CRISPR-Cas9 gene editing technology, these cell lines allow researchers to analyze changes in cellular morphology, migration, and differentiation in the absence of functional DPYSL2. The knockout approach enables comprehensive investigations into its role in neurodegenerative diseases, cancer progression, and other critical biological processes.

Scientifically, these cell lines are invaluable in both research and clinical settings. They provide critical insights into the molecular mechanisms underlying neurological disorders and contribute to the development of targeted therapies. Researchers can employ these cell lines in high-throughput screening assays, giving rise to potential pharmacological agents that may ameliorate the effects of DPYSL2 dysfunction.

Compared to alternative methods of gene manipulation, such as RNA interference or overexpression systems, DPYSL2 Gene Knockout Cell Lines offer a more stable and permanent solution to studying gene function. This long-term modification enables better modeling of in vivo conditions, leading to more reliable experimental outcomes and enhancing overall reproducibility.

The value of DPYSL2 Gene Knockout Cell Lines to researchers, clinicians, and pharmaceutical companies is profound. They enable the exploration of previously uncharacterized pathways and provide a robust platform for drug discovery, ultimately advancing our understanding of complex genetic interactions and their implications for human health.

With years of expertise in genetic engineering and cell line development, our company is committed to delivering high-quality, meticulously characterized biological products that meet the needs of the scientific community. We provide not only innovative tools but also comprehensive support to ensure their optimal application in cutting-edge research and clinical scenarios.

Please note that all services are for research use only. Not intended for any clinical use.

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