Gene: DNAI3
Official Full Name: dynein axonemal intermediate chain 3provided by HGNC
Gene Summary: Enables Arp2/3 complex binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation and negative regulation of cell migration. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27188 | DNAI3 Knockout cell line (HCT 116) | Human | DNAI3 | 1:2~1:4 | Negative | Online Inquiry |
DNAI3 Gene Knockout Cell Lines are a specialized tool designed for researchers who require precise genetic manipulation for the study of human biology and disease mechanisms. These cell lines are engineered to lack the DNAI3 gene, which encodes for a protein playing a critical role in ciliary function and cellular signaling pathways. By eliminating this gene, researchers can explore the functional consequences of DNAI3 deficiency, leading to insights into related disorders such as primary ciliary dyskinesia and certain respiratory diseases.
The primary mechanism of action for DNAI3 Gene Knockout Cell Lines lies in their ability to facilitate the study of gene function through loss-of-function analyses. They provide a controlled environment to evaluate how the absence of DNAI3 affects cellular behaviors, such as motility, ion transport, and response to environmental stressors. This phenotypic characterization is crucial in elucidating the molecular pathways influenced by DNAI3 activity, thereby enhancing our understanding of its role in health and disease.
In scientific research settings, these knockout cell lines are invaluable for validating potential therapeutic targets. They enable researchers to assess the effects of compounds on cell behavior in the absence of the DNAI3 protein, facilitating drug discovery and testing. Furthermore, in clinical settings, understanding the implications of DNAI3 mutations can lead to the development of genetic diagnostics and targeted therapies for affected individuals.
Unique advantages of our DNAI3 Gene Knockout Cell Lines include their high specificity and reproducibility, ensuring reliable experimental outcomes. Unlike alternative models, these cell lines are rigorously validated and characterized, minimizing variability and maximizing the relevance of the findings to human health contexts. This makes them an essential resource for both academic and biopharmaceutical research.
For researchers and clinicians seeking innovative solutions to advance their understanding of complex biological systems, the DNAI3 Gene Knockout Cell Lines represent a cutting-edge product backed by rigorous scientific investigation. Our company has a proven track record in developing high-quality biological products that empower the scientific community, ensuring that your research is both impactful and meaningful.
Please note that all services are for research use only. Not intended for any clinical use.
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