Gene: DMTF1
Official Full Name: cyclin D binding myb like transcription factor 1provided by HGNC
Gene Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32422 | DMTF1 Knockout cell line (HeLa) | Human | DMTF1 | 1:3~1:6 | Negative | Online Inquiry |
KO32423 | DMTF1 Knockout cell line (HCT 116) | Human | DMTF1 | 1:2~1:4 | Negative | Online Inquiry |
KO32424 | DMTF1 Knockout cell line (HEK293) | Human | DMTF1 | 1:3~1:6 | Negative | Online Inquiry |
KO32425 | DMTF1 Knockout cell line (A549) | Human | DMTF1 | 1:3~1:4 | Negative | Online Inquiry |
DMTF1 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the function and implications of the DMTF1 gene, which is known to play a critical role in various cellular processes including cell cycle regulation, apoptosis, and immune responses. By employing the CRISPR-Cas9 gene-editing technique, these cell lines provide a complete knockout of the DMTF1 gene, allowing researchers to investigate the resultant phenotypic changes and molecular pathways affected by the absence of this gene.
The primary mechanism by which these knockout cell lines operate is the disruption of DMTF1 expression, which results in significant alterations in signaling pathways that could be crucial for various disease states, including cancer and autoimmune disorders. By understanding these changes, researchers can gain insights into the role of DMTF1 in tumorigenesis and potential therapeutic approaches.
Scientifically, DMTF1 Gene Knockout Cell Lines are invaluable tools in both basic and applied research. They enable the exploration of gene function, the identification of interacting partners, and the evaluation of drug responses, significantly advancing the field of genomics and personalized medicine. These cell lines serve as essential models in the development of DMTF1-targeted therapies and provide a platform to assess the biological relevance of this gene.
Compared to other genetic models, our DMTF1 Gene Knockout Cell Lines offer higher specificity and reproducibility, due to their robust CRISPR-Cas9 design and careful validation process. This ensures that researchers can trust the reliability of the results derived from experiments utilizing these cell lines, thus enhancing the overall quality of their research.
The comprehensive nature of these knockout cell lines positions them as a valuable asset for both academic and clinical researchers who seek to unravel complex cellular mechanisms underlying diseases and therapeutic responses. Trust in our expertise, backed by years of experience in providing high-quality biological products, to support your groundbreaking research endeavors with DMTF1 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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