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DMRT3 Knockout Cell Lines

Gene: DMRT3

Official Full Name: doublesex and mab-3 related transcription factor 3provided by HGNC

Gene Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18270 DMRT3 Knockout cell line (HEK293) Human DMRT3 1:3~1:6 Negative Online Inquiry

Background

DMRT3 Gene Knockout Cell Lines are precisely engineered cellular models that facilitate the study of DMRT3 gene function by permanently disabling this specific gene. The DMRT3 gene encodes a transcription factor that plays a critical role in various biological processes, including sex determination, development, and specific neural pathways. By utilizing gene knockout techniques, these cell lines provide researchers with the ability to investigate how DMRT3 deficiency affects cellular behavior, gene expression, and molecular pathways.

The key functions of these cell lines operate through the CRISPR-Cas9 gene-editing technology, which allows for targeted disruption of the DMRT3 gene. This approach enables scientists to observe the downstream effects of gene inactivation, shedding light on processes such as differentiation, cellular signaling, and potential implications in developmental disorders or diseases. The experimentations with DMRT3 Knockout Cell Lines can enhance understanding of neurodevelopmental pathways and inform potential therapeutic angles for related conditions.

From a scientific standpoint, the availability of DMRT3 Gene Knockout Cell Lines is foundational for basic research and has translational potential in clinical applications. They provide valuable insights into the genetic components that underpin various biological systems, which is particularly beneficial for geneticists, biologists, and neuroscientists studying gene function and regulation.

Compared to alternative models, such as transient transfection systems or full animal models, DMRT3 Gene Knockout Cell Lines offer several advantages. They provide a stable platform for long-term studies without the genetic variability that might confound results. Additionally, the ease of handling and culturing these cell lines increases accessibility for laboratories and reduces costs associated with housing or maintaining live animals.

Researchers and clinicians are increasingly recognizing the value of these knockout cell lines, especially when developing gene therapies or conducting drug discovery processes aimed at conditions impacted by the DMRT3 gene. The advanced understanding derived from employing these models can lead to more targeted therapeutic strategies.

Our company's commitment to providing high-quality biological products is reinforced by our state-of-the-art gene-editing capabilities and extensive experience in creating tailored research tools. With DMRT3 Gene Knockout Cell Lines, we empower researchers with the means to enhance their investigations and contribute significantly to the field of genetics and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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