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DLX4 Knockout Cell Lines

Gene: DLX4

Official Full Name: distal-less homeobox 4provided by HGNC

Gene Summary: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38228 DLX4 Knockout cell line (HeLa) Human DLX4 1:3~1:6 Negative Online Inquiry
KO38229 DLX4 Knockout cell line (HCT 116) Human DLX4 1:2~1:4 Negative Online Inquiry
KO38230 DLX4 Knockout cell line (HEK293) Human DLX4 1:3~1:6 Negative Online Inquiry
KO38231 DLX4 Knockout cell line (A549) Human DLX4 1:3~1:4 Negative Online Inquiry

Background

DLX4 Gene Knockout Cell Lines are genetically engineered cellular models designed to selectively disrupt the DLX4 gene, a critical transcription factor involved in the development and differentiation of various tissues, including neuronal and hematopoietic systems. By offering a specific knockout of the DLX4 gene, these cell lines facilitate the study of gene function and regulatory pathways under both physiological and pathological conditions.

The key mechanism of the DLX4 Gene Knockout Cell Lines relies on CRISPR-Cas9 or similar genome-editing technologies that create precise modifications in the target gene, leading to the absence of DLX4 protein expression. This allows researchers to investigate the molecular impacts resulting from the loss of DLX4 function, shedding light on its role in embryonic development, neurogenesis, and cellular homeostasis.

In the realm of research and clinical applications, these cell lines are invaluable for studying developmental abnormalities, neurodegenerative diseases, and cancer biology that may arise from aberrant DLX4 functionality. They serve as platforms for drug discovery, functional assays, and gene therapy exploration, ultimately contributing to a deeper understanding of gene regulatory networks.

Compared to traditional knockout methods, such as homologous recombination, our DLX4 Gene Knockout Cell Lines provide a more efficient and precise approach with minimal off-target effects. Furthermore, the availability of well-characterized cell lines can accelerate experimental timelines and enhance reproducibility in scientific studies.

For researchers and clinicians alike, investing in DLX4 Gene Knockout Cell Lines can significantly advance the understanding of complex genetic mechanisms and their implications in human health. Our company prides itself on its commitment to providing high-quality, reliable biological research tools, backed by extensive expertise in genetic engineering and cell line development. Embark on your journey of discovery with confidence, leveraging our innovative products to unlock new frontiers in molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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