Gene: DAAM1
Official Full Name: dishevelled associated activator of morphogenesis 1provided by HGNC
Gene Summary: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11801 | DAAM1 Knockout cell line (HeLa) | Human | DAAM1 | 1:3~1:6 | Negative | Online Inquiry |
KO11802 | DAAM1 Knockout cell line (HCT 116) | Human | DAAM1 | 1:2~1:4 | Negative | Online Inquiry |
KO11803 | DAAM1 Knockout cell line (HEK293) | Human | DAAM1 | 1:3~1:6 | Negative | Online Inquiry |
KO11804 | DAAM1 Knockout cell line (A549) | Human | DAAM1 | 1:3~1:4 | Negative | Online Inquiry |
DAAM1 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of the Dishevelled-associated activator of morphogenesis 1 (DAAM1) gene, a crucial element involved in various cellular processes, including cytoskeletal organization and developmental signaling pathways. These knockout cell lines enable researchers to effectively analyze the functional outcomes of DAAM1 loss, providing insights into its role in cellular motility, polarity, and tissue morphogenesis.
The primary function of DAAM1 is to act as a regulator of the Wnt signaling pathway, a fundamental signaling mechanism that orchestrates numerous biological processes. By employing CRISPR-Cas9 technology, our DAAM1 Gene Knockout Cell Lines exhibit a precise knockout of the DAAM1 gene, ensuring that researchers can meticulously explore the molecular mechanisms underlying its involvement in cellular dynamics and disease progression.
The scientific importance of these knockout cell lines cannot be overstated, as they provide invaluable tools for basic research and clinical applications alike. They are particularly relevant for studies investigating cancer biology and developmental disorders, where aberrant Wnt signaling and related cellular behaviors are implicated. These models facilitate a deeper understanding of therapeutic targets and potential innovations in treatment strategies.
Our DAAM1 Gene Knockout Cell Lines possess distinct advantages over alternative products, such as unparalleled specificity, validated knockout efficiency, and ease of use in experimental setups. Unlike traditional methods of gene silencing, which may lead to incomplete or off-target effects, these knockout lines guarantee an entire loss of DAAM1 function, thereby providing more accurate and reproducible results.
For researchers and clinicians keen on elucidating the complexities of cellular mechanisms and therapeutic development, these cell lines represent a significant advancement in experimental design. They empower users to derive clearer insights, resulting in more informed conclusions and the potential for impactful scientific discoveries.
At [Your Company Name], we pride ourselves on pioneering high-quality biological products supported by rigorous scientific research. Our expertise in gene editing technologies ensures that our DAAM1 Gene Knockout Cell Lines meet the highest standards in research fidelity, enabling a broader swath of the scientific community to explore and understand the implications of DAAM1 loss in physiological and pathological contexts.
Please note that all services are for research use only. Not intended for any clinical use.
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