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CYTH4 Knockout Cell Lines

Gene: CYTH4

Official Full Name: cytohesin 4provided by HGNC

Gene Summary: This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07703 CYTH4 Knockout cell line (HCT 116) Human CYTH4 1:2~1:4 Negative Online Inquiry

Background

CYTH4 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed for the targeted disruption of the CYTH4 gene. This product serves as a powerful tool for researchers studying the biological functions and pathways regulated by CYTH4, a gene implicated in several cellular processes, including signal transduction and lipid metabolism. By utilizing CRISPR-Cas9 technology, these knockout cell lines provide a precise means to elucidate the role of CYTH4 in various physiological contexts and disease states.

The primary function of the CYTH4 Gene Knockout Cell Lines involves the loss-of-function approach, allowing researchers to investigate the phenotypic changes associated with CYTH4 deletion. This gene knockout model aids in the analysis of the consequent alterations in cellular signaling, potentially unveiling novel therapeutic targets for diseases where CYTH4 plays a significant role. The comprehensive characterization of these cell lines, which typically include verification of gene editing efficiency and stability, is crucial for the reliability of experimental outcomes.

The scientific importance of these cell lines extends to both fundamental biological research and clinical applications. In research settings, they serve as vital models for studying metabolic disorders, cancer biology, and neurodegenerative diseases. Clinically, insights gained from CYTH4 function can lead to innovative strategies for personalized medicine, where the modulation of CYTH4 activity could provide therapeutic benefits.

Compared to alternative models, such as wild-type or overexpressing cell lines, CYTH4 Gene Knockout Cell Lines present unique advantages, including the elimination of confounding factors associated with gene overexpression and the ability to observe cellular responses that closely mimic in vivo conditions. This specificity and precision empower researchers to draw more accurate conclusions from their experiments.

For researchers and clinicians focused on advancing our understanding of cellular mechanisms and developing novel therapies, CYTH4 Gene Knockout Cell Lines represent an invaluable asset. Their application can significantly enhance the depth of research findings and contribute toward breakthroughs in various fields of biology and medicine.

At [Company Name], we are committed to advancing scientific research through our innovative product offerings, marked by rigorous quality controls and extensive expertise in genetic engineering technologies. Our CYTH4 Gene Knockout Cell Lines exemplify our dedication to providing superior resources that empower scientists in their quest for knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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