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CYP4F22 Knockout Cell Lines

Gene: CYP4F22

Official Full Name: cytochrome P450 family 4 subfamily F member 22provided by HGNC

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27346 CYP4F22 Knockout cell line (HCT 116) Human CYP4F22 1:2~1:4 Negative Online Inquiry

Background

CYP4F22 Gene Knockout Cell Lines are sophisticated biological tools derived from specific cell lineages that have been genetically engineered to have a targeted deletion of the CYP4F22 gene. This gene encodes for a member of the cytochrome P450 enzyme family, which plays critical roles in the metabolism of various bioactive compounds, including fatty acids and xenobiotics. By knocking out this particular gene, these cell lines allow researchers to study the biochemical pathways and physiological processes that rely on CYP4F22 activity, elucidating its contributions to drug metabolism and lipid signaling.

The primary mechanism of action involves the complete abrogation of CYP4F22 function, enabling researchers to assess changes in metabolic profiles, cellular responses to drugs, and the resultant physiological implications without the confounding influence of CYP4F22 enzyme activity. This provides a clearer understanding of gene function and its involvement in specific diseases, such as skin conditions and metabolic disorders.

Scientifically, these knockout cell lines are invaluable in research contexts, facilitating in vitro studies that may lead to advancements in pharmacotherapeutics or the development of new treatment strategies for conditions linked to aberrant metabolic signaling. Clinically, they offer a platform for screening potential therapeutics aimed at diseases where CYP4F22 is implicated.

Compared to alternatives such as wild-type cell lines or other gene editing techniques, CYP4F22 Gene Knockout Cell Lines present a more specific and direct approach to investigate the cellular impact of gene loss. Their precise genetic modification significantly enhances the validity of research findings, positioning them as a superior choice for researchers aiming for precision in their experimental designs.

For researchers, clinicians, and pharmaceutical developers committed to advancing our understanding of metabolic processes and drug interactions, CYP4F22 Gene Knockout Cell Lines represent a highly valuable asset. Utilizing these cell lines can streamline research workflows and accelerate the identification of therapeutic targets, particularly in metabolic diseases.

Our company is dedicated to pioneering cutting-edge biological solutions, providing high-quality gene knockout models that empower the scientific community to make significant headway in genetic and metabolic research.

Please note that all services are for research use only. Not intended for any clinical use.

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