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CXXC4 Knockout Cell Lines

Gene: CXXC4

Official Full Name: CXXC finger protein 4provided by HGNC

Gene Summary: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11805 CXXC4 Knockout cell line (HeLa) Human CXXC4 1:3~1:6 Negative Online Inquiry

Background

CXXC4 Gene Knockout Cell Lines are genetically modified cell lines designed to provide researchers with an invaluable tool for studying the role of the CXXC4 gene in various biological processes. The CXXC4 gene, also known as IDAX, encodes a protein that plays a pivotal role in cellular signaling pathways, particularly in the regulation of Wnt signaling, which is crucial for developmental processes and cell differentiation. By employing CRISPR-Cas9 gene-editing technology, these knockout cell lines effectively disrupt the CXXC4 gene, enabling researchers to observe the downstream effects and elucidate the mechanistic pathways influenced by this gene's dysregulation.

The primary function of CXXC4 Gene Knockout Cell Lines lies in their ability to facilitate in-depth research into the implications of CXXC4 on cell behavior, including proliferation, apoptosis, and interaction with other signaling pathways. This platform allows for robust experimentation, providing insights that are essential for both basic research and the development of targeted therapies, especially in the context of diseases such as cancer where Wnt signaling is often compromised.

What sets these cell lines apart from other gene knockout models is their precise modification and the high efficiency of the CRISPR-Cas9 system employed. Researchers can rely on their reproducibility and genetic stability for long-term experiments. Additionally, these cell lines are readily adaptable to various experimental conditions, making them extremely versatile for a wide range of biological assays.

The significance of CXXC4 Gene Knockout Cell Lines extends to clinical applications, including drug discovery and personalized medicine. By studying CXXC4 knockout scenarios, scientists can identify potential drug targets and therapeutic pathways that may lead to novel treatments.

Our company specializes in the production of high-quality genetic models, ensuring that each CXXC4 Gene Knockout Cell Line meets rigorous standards for reliability and performance. By choosing our products, researchers gain access to advanced biological tools that can significantly enhance the understanding of complex genetic mechanisms, ultimately driving forward the frontiers of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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