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CTSC Knockout Cell Lines

Gene: CTSC

Official Full Name: cathepsin Cprovided by HGNC

Gene Summary: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00494 CTSC Knockout cell line (HCT 116) Human CTSC 1:2~1:4 Negative Online Inquiry
KO03381 CTSC Knockout cell line (HeLa) Human CTSC 1:3~1:6 Negative Online Inquiry
KO03382 CTSC Knockout cell line (HEK293) Human CTSC 1:3~1:6 Negative Online Inquiry
KO03383 CTSC Knockout cell line (A549) Human CTSC 1:3~1:4 Negative Online Inquiry

Background

CTSC Gene Knockout Cell Lines represent a cutting-edge biological tool designed for the precise manipulation of gene expression through targeted deletions. These specially engineered cell lines are derived from established human or animal cell lines, specifically modified to eliminate the expression of the cathepsin S (CTSC) gene. This knockout model facilitates researchers in studying the functional roles of CTSC in various biological processes, including immune response, cancer progression, and extracellular matrix remodeling.

The primary function of CTSC Gene Knockout Cell Lines lies in their ability to mimic pathological conditions by attenuating or completely abolishing CTSC function. Researchers utilize techniques such as CRISPR-Cas9, homologous recombination, or RNA interference to achieve gene knockout, allowing for a comprehensive understanding of CTSC's involvement in specific cellular pathways and disease mechanisms. This functionality not only enhances the depth of biological inquiry but also accelerates the development of innovative therapeutic strategies targeting CTSC-related diseases.

The scientific significance of CTSC Gene Knockout Cell Lines extends across both fundamental and applied research domains. In clinical settings, these cell lines can serve as valuable platforms for drug screening and the validation of therapeutic candidates, specifically those aimed at modulating CTSC activity. Moreover, they foster advancements in regenerative medicine and cancer therapies, where understanding the gene's role is vital for developing effective treatments.

What sets CTSC Gene Knockout Cell Lines apart from existing alternatives is their rigorously validated performance, ensuring consistency and reproducibility in experimental outcomes. They offer researchers a reliable resource for complex gene-function studies while also enabling high-throughput screening capabilities, which can significantly save time and resources. Additionally, these cell lines come with a detailed characterization and comprehensive support for optimal use, further enhancing their utility.

Researchers, clinicians, and pharmaceutical companies can greatly benefit from the innovative capabilities provided by CTSC Gene Knockout Cell Lines. With our commitment to advancing scientific discoveries, our company leverages years of expertise in cell biology and genetic engineering to deliver high-quality and reliable biological products essential for modern research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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