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CTIF Knockout Cell Lines

Gene: CTIF

Official Full Name: cap binding complex dependent translation initiation factorprovided by HGNC

Gene Summary: CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32734 CTIF Knockout cell line (HeLa) Human CTIF 1:3~1:6 Negative Online Inquiry
KO32735 CTIF Knockout cell line (HCT 116) Human CTIF 1:2~1:4 Negative Online Inquiry
KO32736 CTIF Knockout cell line (HEK293) Human CTIF 1:3~1:6 Negative Online Inquiry
KO32737 CTIF Knockout cell line (A549) Human CTIF 1:3~1:4 Negative Online Inquiry

Background

CTIF Gene Knockout Cell Lines are meticulously developed cellular models featuring targeted deletions of the CTIF gene, a critical component in the regulation of protein synthesis and cellular stress responses. These knockout cell lines utilize CRISPR-Cas9 technology to create specific and heritable gene modifications, allowing researchers to investigate the functional consequences of CTIF depletion in various biological contexts.

The primary function of CTIF Gene Knockout Cell Lines is to facilitate the delineation of the CTIF gene's role in translation initiation, mRNA splicing, and the cellular response to external stimuli. By manipulating the expression of this gene, researchers can observe the resulting phenotypic changes, which provides invaluable insights into mechanisms underlying various diseases, including cancer and neurological disorders. Through the use of these knockout models, scientists can elucidate gene function and assess potential therapeutic targets.

The scientific importance of CTIF Gene Knockout Cell Lines cannot be overstated. These tools represent a significant advancement in molecular biology, offering precise and reproducible models that contribute to our understanding of gene function in health and disease. Their application spans both basic research and clinical contexts, enabling the exploration of new approaches in drug development and personalized medicine.

One of the distinguishing advantages of CTIF Gene Knockout Cell Lines over traditional cell lines or gene-silencing techniques, such as RNA interference, is their ability to provide a stable and complete gene knockout, which leads to more accurate and consistent results. Furthermore, these models are versatile and can be utilized in a wide range of experimental setups, including high-throughput screens for drug discovery.

For researchers and clinicians looking for reliable models to investigate gene function and its implications in disease pathology, CTIF Gene Knockout Cell Lines offer a powerful and robust tool. Our company’s expertise in advanced genetic editing technologies ensures that our products are of the highest quality, enabling scientists to pursue groundbreaking research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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