Gene: COL5A2
Official Full Name: collagen type V alpha 2 chainprovided by HGNC
Gene Summary: This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07035 | COL5A2 Knockout cell line (HCT 116) | Human | COL5A2 | 1:2~1:4 | Negative | Online Inquiry |
KO07036 | COL5A2 Knockout cell line (HEK293) | Human | COL5A2 | 1:3~1:6 | Negative | Online Inquiry |
KO07037 | COL5A2 Knockout cell line (A549) | Human | COL5A2 | 1:3~1:4 | Negative | Online Inquiry |
COL5A2 Gene Knockout Cell Lines represent a cutting-edge innovation in genetic research, specifically tailored for studies targeting the collagen type V alpha 2 chain, a vital component in the extracellular matrix. These cell lines have been meticulously engineered using CRISPR/Cas9 technology to create stable gene knockouts, allowing researchers to elucidate the functional role of COL5A2 in cellular processes such as matrix assembly, tissue structure, and pathology associated with connective tissue disorders.
The primary function of these knockout cell lines is to provide a controlled environment for investigating the pathway alterations that occur when COL5A2 is absent. By utilizing these cell lines, scientists can analyze changes in cellular behavior, gene expression, and protein interactions, facilitating a deeper understanding of how alterations in COL5A2 contribute to various diseases, particularly fibrotic and degenerative disorders.
The scientific importance of COL5A2 Gene Knockout Cell Lines is underscored by their diverse applications in both research and clinical settings. They serve as valuable tools for drug discovery, enabling the identification of potential therapeutic targets, as well as in the development of regenerative medicine strategies. Furthermore, they play a crucial role in validating the functions of gene variants associated with genetic disorders.
One of the standout advantages of our COL5A2 knockout cell lines is their reliability and reproducibility, attributes critical for obtaining robust and interpretable data. The precision of the CRISPR technology employed ensures specific gene editing with minimal off-target effects, setting these cell lines apart from traditional models that may exhibit genetic drift or mosaicism.
Investing in COL5A2 Gene Knockout Cell Lines means equipping researchers and clinicians with a powerful resource that opens new avenues for discovery and therapeutic development. Our commitment to delivering high-quality biological products is backed by our extensive expertise in genetic engineering and cellular biology, making these cell lines a valuable addition to any research program focused on extracellular matrix dynamics and related pathologies.
Please note that all services are for research use only. Not intended for any clinical use.
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