Gene: CLIC2
Official Full Name: chloride intracellular channel 2provided by HGNC
Gene Summary: This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38515 | CLIC2 Knockout cell line (HeLa) | Human | CLIC2 | 1:3~1:6 | Negative | Online Inquiry |
CLIC2 Gene Knockout Cell Lines consist of genetically modified cellular models specifically engineered to lack the functional CLIC2 gene. CLIC2 (Chloride Intracellular Channel 2) functions primarily as an ion channel involved in the regulation of cellular chloride levels, and its knockout serves as a critical tool in elucidating its role in various physiological and pathological processes. These specialized cell lines effectively mimic the absence of CLIC2, allowing researchers to explore downstream effects on cellular signaling, ion homeostasis, and influence on various biological pathways.
The primary function of CLIC2 knockout cell lines lies in their capacity to serve as comparative models. By contrasting these cell lines with wild-type counterparts, researchers can investigate the functional roles of CLIC2 in cellular processes such as apoptosis, proliferation, and migration. The knockout mechanism, typically achieved through CRISPR-Cas9 gene editing technology, ensures precise deletion of the CLIC2 gene, enabling robust studies on how its absence alters cellular behavior.
The scientific importance of CLIC2 knockout cell lines extends into both research and clinical settings, where understanding the implications of CLIC2 dysfunction may have substantial relevance in conditions such as cancer, cardiovascular diseases, and neurological disorders. Researchers can utilize these models to uncover novel therapeutic targets and biomarkers, advancing the knowledge in molecular biology and translational medicine.
What sets our CLIC2 Gene Knockout Cell Lines apart from alternatives available in the market is our commitment to rigorous validation processes ensuring high purity and functional integrity. We offer a user-friendly catalog with extensive background data, facilitating straightforward experimental design and expedited results.
The value of CLIC2 Gene Knockout Cell Lines to researchers and clinicians lies in their reliability and ability to generate reproducible results, ultimately driving forward hypothesis testing and therapeutic development. With a proven history of successful product offerings and a dedicated team of experts in genetic modifications and cell line development, our company remains at the forefront of providing advanced biological research tools tailored to meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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