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CHRDL2 Knockout Cell Lines

Gene: CHRDL2

Official Full Name: chordin like 2provided by HGNC

Gene Summary: This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28685 CHRDL2 Knockout cell line (HeLa) Human CHRDL2 1:3~1:6 Negative Online Inquiry
KO28686 CHRDL2 Knockout cell line (A549) Human CHRDL2 1:3~1:4 Negative Online Inquiry

Background

CHRDL2 Gene Knockout Cell Lines are expertly designed cellular systems in which the CHRDL2 gene has been functionally disrupted, creating a powerful tool for researchers studying developmental biology and disease mechanisms. CHRDL2, known for its role in extracellular matrix regulation and its involvement in various pathophysiological processes, including cancer progression and neurodevelopmental disorders, becomes a focal point in understanding cellular dynamics following knockout.

The knockout mechanism employs precise gene-editing technologies, such as CRISPR-Cas9, to ensure a complete and effective deletion of the CHRDL2 gene. This allows for the meticulous observation of the resultant phenotypic and biochemical changes, thereby elucidating the gene's specific functions and interactions within cellular pathways. Researchers can investigate altered signaling pathways, cellular proliferation, and differentiation processes, providing critical insights into how CHRDL2 contributes to health and disease.

The scientific importance of CHRDL2 Gene Knockout Cell Lines extends to both basic and applied research. In clinical settings, these cell lines serve as valuable models for drug discovery and therapeutic development, allowing for the testing of interventions targeting CHRDL2-related disorders. This model not only facilitates understanding of gene function but also aids in identifying potential biomarkers for disease that could translate into impactful clinical applications.

Comparatively, these cell lines offer distinct advantages over traditional models by providing a more accurate recapitulation of human disease states. Unlike other cell lines, CHRDL2 knockout variants allow for the specific exploration of gene function in a homogenous cellular background, ensuring experimental reproducibility and reliability of results.

The value of CHRDL2 Gene Knockout Cell Lines to researchers and clinicians lies in their capacity to accelerate discovery and innovation in the field of molecular biology. By utilizing these sophisticated models, users can advance their understanding of gene functions and their implications in various diseases, ultimately contributing to improved therapeutic strategies.

Our company is dedicated to delivering high-quality biological products backed by extensive scientific expertise and commitment to reliability. We empower researchers with innovative tools like the CHRDL2 Gene Knockout Cell Lines, designed to elevate your research and clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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