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CHAC2 Knockout Cell Lines

Gene: CHAC2

Official Full Name: ChaC glutathione specific gamma-glutamylcyclotransferase 2provided by HGNC

Gene Summary: The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18751 CHAC2 Knockout cell line (HeLa) Human CHAC2 1:3~1:6 Negative Online Inquiry
KO18752 CHAC2 Knockout cell line (HCT 116) Human CHAC2 1:2~1:4 Negative Online Inquiry
KO18753 CHAC2 Knockout cell line (HEK293) Human CHAC2 1:3~1:6 Negative Online Inquiry
KO18754 CHAC2 Knockout cell line (A549) Human CHAC2 1:3~1:4 Negative Online Inquiry

Background

CHAC2 Gene Knockout Cell Lines are genetically engineered cell lines that have had the CHAC2 gene inactivated, enabling researchers to study its functional role and implications in various biological processes. CHAC2, known to play a significant part in cellular metabolism and stress response, is implicated in the regulation of cellular apoptosis and inflammation. The knockout of this gene creates a unique model that facilitates the dissection of these pathways, thus providing insights into mechanisms underlying diseases such as cancer and neurodegenerative disorders.

The primary function of CHAC2 Gene Knockout Cell Lines involves the elimination of CHAC2 protein production, leading to alterations in glutathione metabolism and reactive oxygen species (ROS) management. This knockout approach allows scientists to observe changes in cellular behavior, specifically how these cells respond to oxidative stress and other stimuli that could be modulated by CHAC2 activity. Such insights are essential for understanding the complex interactions that occur during disease progression.

Scientifically, these cell lines are invaluable tools in research settings, bridging the gap between basic research and clinical applications. They enable the exploration of therapeutic targets aimed at modulating the effects of CHAC2, informing drug development and contributing to understanding potential interventions in related pathologies.

Compared to alternatives, such as transient transfection methods or RNA interference techniques, CHAC2 Gene Knockout Cell Lines offer a stable genetic modification that ensures consistent expression and phenotypic outcomes across experiments. This stability is crucial for longitudinal studies aimed at deciphering cell-signaling pathways and can save time and resources associated with repeated experiments.

For researchers and clinicians, the ability to study knockout models like CHAC2 is not just a technical advantage but a vital step towards developing molecularly targeted therapies that can improve patient outcomes. By employing these specialized cell lines, users can significantly enhance their research capabilities and product development processes, ultimately driving progress in the field.

Our company specializes in the production of high-quality, genetically modified cell lines, backed by a team of experts in molecular biology and genetics. We are committed to providing innovative solutions that empower researchers and clinicians in their quest for discovery and therapeutic advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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