Gene: CFAP410
Official Full Name: cilia and flagella associated protein 410provided by HGNC
Gene Summary: Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients. [provided by RefSeq, Sep 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38738 | CFAP410 Knockout cell line (HeLa) | Human | CFAP410 | 1:3~1:6 | Negative | Online Inquiry |
KO38739 | CFAP410 Knockout cell line (HCT 116) | Human | CFAP410 | 1:2~1:4 | Negative | Online Inquiry |
KO38740 | CFAP410 Knockout cell line (HEK293) | Human | CFAP410 | 1:3~1:6 | Negative | Online Inquiry |
KO38741 | CFAP410 Knockout cell line (A549) | Human | CFAP410 | 1:3~1:4 | Negative | Online Inquiry |
CFAP410 Gene Knockout Cell Lines are advanced biological tools designed to facilitate comprehensive research in gene function and cellular mechanisms. These cell lines have been engineered to contain a targeted knockout of the CFAP410 gene, which encodes a protein implicated in the structure and function of cilia and flagella, essential components in numerous cellular processes, including motility, sensory perception, and signaling pathways. By removing the CFAP410 gene, researchers can investigate the resultant phenotypic changes, thereby obtaining insights into the gene's role in health and disease.
The primary mechanism by which CFAP410 Gene Knockout Cell Lines function involves CRISPR/Cas9 technology, allowing for precise and efficient gene editing. This methodology not only generates stable cell lines with a complete loss of CFAP410 expression but also enables the study of compensatory pathways that may be activated in the absence of this gene. As such, these knockout models are vital tools for elucidating the underlying biology related to cilia-related disorders, including respiratory and reproductive system dysfunctions.
In both research and clinical settings, CFAP410 knockout models hold significant importance. They serve as crucial systems for drug discovery and testing, providing a platform to screen potential therapeutics targeting ciliary dysfunction. Additionally, their ability to model human disease allows researchers to explore the molecular basis of ciliary disorders more effectively than non-human models.
What sets our CFAP410 Gene Knockout Cell Lines apart from alternatives is their comprehensive validation and characterization, which ensures reproducible results. Each cell line undergoes rigorous quality control measures, including off-target analysis and functional assays, thus assuring the accuracy and reliability required for high-stakes research.
For researchers and clinicians alike, these cell lines represent an invaluable resource in the quest to understand complex biological systems and develop potential interventions for related diseases. Our commitment to excellence in quality and innovation is exemplified in our expertise in gene editing technologies and development of high-caliber biological products, ensuring that our customers have access to the best tools for their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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