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CFAP221 Knockout Cell Lines

Gene: CFAP221

Official Full Name: cilia and flagella associated protein 221provided by HGNC

Gene Summary: Predicted to enable calmodulin binding activity. Predicted to be involved in motile cilium assembly. Predicted to act upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and sperm flagellum assembly. Predicted to be located in axoneme; glial cell projection; and manchette. Predicted to be active in 9+2 motile cilium. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38166 CFAP221 Knockout cell line (HEK293) Human CFAP221 1:3~1:6 Negative Online Inquiry

Background

CFAP221 Gene Knockout Cell Lines represent a cutting-edge tool in genetic research and biotechnology, specifically designed for the functional analysis of the CFAP221 gene, which encodes for a protein integral to ciliary structure and function. This product features a series of genetically modified cell lines in which the CFAP221 gene has been effectively disrupted through CRISPR-Cas9 technology, enabling researchers to elucidate the gene's role in cellular processes and disease mechanisms.

The primary function of these knockout cell lines lies in their ability to facilitate targeted studies in cilium-related functions, including motility and signaling pathways that are crucial for tissue homeostasis. By observing the phenotypic and molecular changes in these cells, scientists can gain insights into ciliopathies, which are disorders arising from dysfunctional cilia, such as primary ciliary dyskinesia and Bardet-Biedl syndrome. The knockout model serves as a powerful platform for investigating the consequences of CFAP221 loss and its implications in various human diseases.

In terms of scientific importance, CFAP221 Gene Knockout Cell Lines are invaluable tools in both basic research and clinical applications. They enable high-throughput screening for potential therapeutic interventions and support advancements in gene therapy approaches. Their relevance extends beyond academic research settings to pharmaceutical and clinical environments where understanding ciliary dynamics and associated disorders is vital.

One of the key advantages of our CFAP221 Gene Knockout Cell Lines is their specificity and reproducibility, resulting from the precise CRISPR-Cas9 gene editing methodology applied during development. This ensures reliable experimental outcomes, thus reducing variability often seen with alternative gene knockout techniques such as traditional homologous recombination. Additionally, the cell lines come with comprehensive datasets and user protocols, ensuring ease of use and integration into existing workflows.

For researchers and clinicians aiming to push the boundaries of ciliary research, our CFAP221 Gene Knockout Cell Lines are indispensable. They provide a robust framework for investigating genetic contributions to ciliary dysfunction, facilitating the translation of research findings into clinical breakthroughs.

As a leader in biotechnological innovation, our company specializes in producing high-quality genetic models and reagents, underpinned by years of scientific expertise. Our commitment to supporting research excellence is reflected in the reliability of our products, ensuring they remain at the forefront of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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