Home / CELF5 Knockout Cell Lines

CELF5 Knockout Cell Lines

Gene: CELF5

Official Full Name: CUGBP Elav-like family member 5provided by HGNC

Gene Summary: This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18839 CELF5 Knockout cell line (HCT 116) Human CELF5 1:2~1:4 Negative Online Inquiry

Background

CELF5 Gene Knockout Cell Lines are innovative tools designed for the targeted study of the CELF5 gene's role in cellular biology. These cell lines are engineered to exhibit a complete knockout of the CELF5 gene, allowing researchers to investigate the gene's function in post-transcriptional regulation, alternative splicing, and its implications in various pathological conditions. By utilizing CRISPR-Cas9 technology or similar gene-editing techniques, these cell lines provide a versatile platform for studying gene function and gene interaction pathways.

The key function of CELF5 Gene Knockout Cell Lines lies in their ability to mimic loss-of-function scenarios, enabling researchers to delineate the specific contributions of CELF5 to cellular processes. In particular, CELF5 is known to play critical roles in regulating mRNA stability and translation, which are pivotal in understanding disease mechanisms such as cancer, neurodegenerative disorders, and developmental defects. The knockout model provides a straightforward approach to investigate the downstream effects of CELF5 deficiency and aids in identifying compensatory mechanisms within cellular networks.

Scientifically, these cell lines hold significant importance in both basic research and clinical applications. They facilitate the discovery of novel therapeutic targets and enhance the understanding of disease pathology linked to aberrant splicing and gene regulation. Researchers can also use these models in drug discovery processes to evaluate the efficacy of potential therapeutic compounds targeting the pathways influenced by CELF5.

The specific advantages of our CELF5 Gene Knockout Cell Lines stem from their high specificity and reproducibility compared to traditional knockdown methods. They allow for stable gene inactivation, eliminating concerns related to off-target effects and transient expression, which are common in RNA interference approaches. Moreover, we employ rigorous validation procedures to ensure the reliability of these cell lines, providing researchers with confidence in their experimental outcomes.

For researchers and clinicians focused on advancing their understanding of genetic contributions to disease, our CELF5 Gene Knockout Cell Lines represent a valuable asset. By offering precise and robust models for the exploration of CELF5-related pathways, we empower users to uncover critical insights that might lead to innovative therapeutic strategies.

As a leader in developing high-quality biological products, our company is committed to providing researchers with advanced tools that facilitate groundbreaking scientific discoveries. Our dedication to quality and innovation ensures that the CELF5 Gene Knockout Cell Lines will effectively enhance your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.