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CCDC8 Knockout Cell Lines

Gene: CCDC8

Official Full Name: coiled-coil domain containing 8provided by HGNC

Gene Summary: This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05096 CCDC8 Knockout cell line (HEK293) Human CCDC8 1:3~1:6 Negative Online Inquiry

Background

CCDC8 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the CCDC8 gene, a critical component involved in cellular processes such as cilia formation and cellular signaling. These knockout models provide researchers with an invaluable tool to investigate the functional consequences of CCDC8 deletion, allowing for the study of its role in various biological pathways and disease mechanisms, particularly in conditions related to ciliary dysfunction.

The primary function of CCDC8 is associated with the regulation of ciliary length and the assembly of ciliary structures, which are essential for the functioning of numerous cell types. By utilizing these knockout cell lines, researchers can explore how the absence of CCDC8 affects cellular behavior, signaling cascades, and the overall physiological implications on tissue and organ systems. This can lead to groundbreaking discoveries, particularly in the fields of developmental biology, genetics, and molecular pathology, where the understanding of ciliary function plays a crucial role in several hereditary disorders.

In comparison to other available models, CCDC8 Gene Knockout Cell Lines stand out due to their precise genetic modification that ensures the complete loss of function of the target gene. Unlike transient knockdown approaches, these cell lines maintain stable genetic edits, enabling prolonged and reproducible studies. Additionally, they provide a platform for high-throughput screening of therapeutic compounds that may target pathways influenced by CCDC8.

The value of CCDC8 Gene Knockout Cell Lines extends beyond research; they are essential for advancing therapeutic strategies and understanding diseases such as Bardet-Biedl syndrome and other ciliopathies. By utilizing these cell lines, researchers and clinicians can unlock new avenues for diagnosis and treatment, ultimately improving patient outcomes.

Our company prides itself on its commitment to producing high-quality biological tools backed by extensive experience in genetic engineering. We continuously strive to empower researchers with innovative products that facilitate vital scientific inquiry and advancement in medical research.

Please note that all services are for research use only. Not intended for any clinical use.

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