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CBARP Knockout Cell Lines

Gene: CBARP

Official Full Name: CACN subunit beta associated regulatory proteinprovided by HGNC

Gene Summary: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in negative regulation of calcium ion-dependent exocytosis and negative regulation of voltage-gated calcium channel activity. Predicted to be located in growth cone and secretory granule. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21121 CBARP Knockout cell line (HeLa) Human CBARP 1:3~1:6 Negative Online Inquiry
KO21122 CBARP Knockout cell line (HCT 116) Human CBARP 1:2~1:4 Negative Online Inquiry
KO21123 CBARP Knockout cell line (HEK293) Human CBARP 1:3~1:6 Negative Online Inquiry

Background

CBARP Gene Knockout Cell Lines are advanced biological tools engineered to facilitate the study of the CBARP gene's role in various cellular processes. These cell lines are created using CRISPR-Cas9 technology, enabling precise gene editing that results in loss-of-function mutations of the CBARP gene, allowing researchers to elucidate its function in cellular signaling, disease states, and therapeutic responses.

The key mechanism behind these cell lines involves the targeted introduction of double-strand breaks in the genomic DNA at specific CBARP loci. This guides the cellular repair machinery to result in non-homologous end joining (NHEJ), which effectively disrupts the gene's coding sequence. As a consequence, researchers can investigate the biological implications of CBARP deficiency, including metabolic pathways, cell proliferation, and apoptotic responses. This model is pivotal in deciphering the gene's potential role in pathology, particularly in cancer and metabolic disorders.

From a scientific perspective, CBARP Gene Knockout Cell Lines are invaluable in both fundamental and applied research. They serve as a cornerstone for drug discovery and validation, helping to identify potential targets for therapeutic intervention. Furthermore, these cell lines enhance the ability to perform high-throughput screening and functional assays, ultimately leading to the development of strategies that may mitigate disease processes in clinical settings.

One significant advantage of utilizing CBARP Gene Knockout Cell Lines over traditional knockdown models is their permanent alteration of the gene, ensuring more reliable and stable experimental outcomes. In contrast to transient knockdowns that may reverse in subsequent cell generations, the knockout approach provides researchers with a robust platform for long-term studies.

Researchers and clinicians can greatly benefit from the insights derived from these specialized models, particularly in the pursuit of understanding complex diseases and developing novel therapies. The unique ability to explore the CBARP gene's functions with enhanced accuracy marks a substantial advancement in molecular biology research.

Our company brings years of expertise in gene editing technologies and cell line development to the forefront of scientific innovation. By offering state-of-the-art CBARP Gene Knockout Cell Lines, we empower researchers to make significant breakthroughs that advance both academic and clinical knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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