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C5 Knockout Cell Lines

Gene: C5

Official Full Name: complement C5provided by HGNC

Gene Summary: This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38755 C5 Knockout cell line (HeLa) Human C5 1:3~1:6 Negative Online Inquiry
KO38756 C5 Knockout cell line (A549) Human C5 1:3~1:4 Negative Online Inquiry

Background

C5 Gene Knockout Cell Lines are sophisticated biological tools specifically engineered to enable the precise study of gene function and the genetic interactions within cellular pathways. These cell lines have been meticulously developed through CRISPR-Cas9 technology to achieve the knockout of the C5 gene, which plays a crucial role in the complement system, an integral part of the innate immune response. By removing this gene, researchers can investigate its role in various biological processes, including inflammation, immune response modulation, and disease pathology.

The key function of C5 gene knockout cell lines lies in their ability to facilitate a deeper understanding of specific cellular behaviors and molecular mechanisms. Upon knockout of the C5 gene, downstream effects can be closely monitored, allowing for insights into how C5 influences cellular survival, proliferation, and response to stimuli. This mechanism serves as a valuable platform for elucidating the gene's involvement in immune-related diseases and conditions, providing avenues for potential therapeutic interventions.

Scientifically, these cell lines are pivotal in both research and clinical settings. They can be utilized in drug discovery, toxicology studies, and the development of immune therapies, thereby contributing significantly to the advancement of personalized medicine. The knockout of the C5 gene aids in the exploration of conditions such as atypical hemolytic uremic syndrome (aHUS) and other complement-mediated diseases, making these cell lines indispensable to researchers focused on immune dysregulation.

What sets our C5 gene knockout cell lines apart from traditional models is their highly reproducible results and the streamlined process for gene targeting, reducing the time and resources typically associated with creating knockout models. Additionally, our cell lines come with comprehensive documentation and support, ensuring that users can effectively integrate them into their research protocols.

For researchers and clinicians dedicated to pioneering advancements in immunology and gene therapy, these cell lines offer unparalleled value. Their application not only enhances understanding of gene function but also fosters innovative approaches to treating complex diseases. At [Your Company], we pride ourselves on our expertise in cellular and molecular biology, providing high-quality products that drive forward scientific inquiry and clinical breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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