Gene: BTN3A3
Official Full Name: butyrophilin subfamily 3 member A3provided by HGNC
Gene Summary: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31931 | BTN3A3 Knockout cell line (HeLa) | Human | BTN3A3 | 1:3~1:6 | Negative | Online Inquiry |
KO31932 | BTN3A3 Knockout cell line (HCT 116) | Human | BTN3A3 | 1:2~1:4 | Negative | Online Inquiry |
KO31933 | BTN3A3 Knockout cell line (HEK293) | Human | BTN3A3 | 1:3~1:6 | Negative | Online Inquiry |
KO31934 | BTN3A3 Knockout cell line (A549) | Human | BTN3A3 | 1:3~1:4 | Negative | Online Inquiry |
BTN3A3 Gene Knockout Cell Lines are specialized cell models engineered to lack the BTN3A3 gene, which encodes a protein involved in immune system modulation. These knockout cell lines serve as invaluable tools for understanding the complex roles that BTN3A3 plays in immune responses and its interactions with various immune cells. By eliminating the expression of BTN3A3, researchers can observe the resulting phenotypic and functional changes, thereby elucidating the gene's specific contributions to immune regulation and potential pathological states.
The primary function of these knockout cell lines is to facilitate studies into the effects of displacing BTN3A3 on cellular signaling pathways, antigen presentation, and T cell activation. This mechanistic understanding paves the way for research into autoimmune diseases, cancer immunotherapy, and infectious diseases. BTN3A3 influences the activation of γδ T cells, a unique subset of T lymphocytes, offering insights into therapeutic approaches that could enhance immune responses against tumors or modulate them in autoimmune conditions.
The scientific importance of BTN3A3 Gene Knockout Cell Lines cannot be overstated. They are essential for researchers intending to examine the role of BTN3A3 across various models of disease or investigate alternative immune checkpoints. Compared to other knockout models, these cell lines specifically target the BTN3A3 pathway, providing a focused approach to explore the complexities of immune interactions without the confounding effects associated with broader gene knockouts.
For researchers and clinicians, the value of these cell lines lies in their ability to improve experimental reproducibility and provide clearer insights into immune mechanism disruptions. They facilitate targeted drug screening and the development of immunotherapies, which are crucial for advancing clinical treatments.
With a commitment to innovation in biological research tools, our company leverages advanced genetic engineering techniques and extensive expertise in immunology to offer high-quality BTN3A3 Gene Knockout Cell Lines. We provide researchers with reliable and effective resources, enabling groundbreaking discoveries that can translate into tangible clinical outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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