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BTC Knockout Cell Lines

Gene: BTC

Official Full Name: betacellulinprovided by HGNC

Gene Summary: This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38769 BTC Knockout cell line (HCT 116) Human BTC 1:2~1:4 Negative Online Inquiry
KO38770 BTC Knockout cell line (A549) Human BTC 1:3~1:4 Negative Online Inquiry

Background

BTC Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed for the targeted disruption of gene function in various cellular contexts. These engineered cell lines provide researchers with invaluable resources for studying the effects of gene loss-of-function on cellular physiology, differentiation, and disease progression. Utilizing CRISPR-Cas9 gene editing technology, BTC Gene Knockout Cell Lines ensure high efficiency and specificity in gene targeting, enabling scientists to create precise models that mimic genetic conditions.

The primary mechanism of BTC Gene Knockout Cell Lines involves the introduction of double-strand breaks at specific gene loci, which are then repaired by non-homologous end joining (NHEJ), often resulting in mutations that disrupt gene expression. This results in the loss of functional protein production, allowing researchers to assess the downstream effects of gene knockout in various contexts, such as signal transduction pathways, metabolic processes, and cellular responses to stress and pharmacological agents.

Scientifically, these cell lines are vital for advancing research in fields such as cancer biology, regenerative medicine, and personalized therapeutics. Researchers can utilize BTC Gene Knockout Cell Lines to identify key genetic drivers of disease, test potential therapeutic interventions, and explore the biological relevance of specific genes. Their application spans both academic research and clinical settings, contributing to a deeper understanding of genetic diseases and facilitating the development of innovative treatments.

What sets BTC Gene Knockout Cell Lines apart from similar products on the market is their comprehensive validation process and the extensive support provided. Each cell line is meticulously characterized for gene loss, off-target effects, and functional consequences, ensuring reliable performance in experiments. Additionally, users benefit from our company’s deep expertise in genetic engineering and cell biology, fostering a collaborative approach to troubleshooting and optimizing experimental design.

For researchers and clinicians dedicated to unraveling the complexities of gene function, BTC Gene Knockout Cell Lines are an indispensable resource that not only enhances the potential for groundbreaking discoveries but also accelerates the transition of laboratory findings into tangible clinical applications. Our commitment to quality and innovation reflects our leadership in the field, providing customers with the tools they need to drive scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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