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BRAP Knockout Cell Lines

Gene: BRAP

Official Full Name: BRCA1 associated proteinprovided by HGNC

Gene Summary: The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08865 BRAP Knockout cell line (HeLa) Human BRAP 1:3~1:6 Negative Online Inquiry
KO08866 BRAP Knockout cell line (HCT 116) Human BRAP 1:2~1:4 Negative Online Inquiry
KO08867 BRAP Knockout cell line (HEK293) Human BRAP 1:3~1:6 Negative Online Inquiry
KO08868 BRAP Knockout cell line (A549) Human BRAP 1:3~1:4 Negative Online Inquiry

Background

BRAP Gene Knockout Cell Lines are specially engineered cellular models that have been genetically modified to disrupt the expression of the BRAP gene, a critical regulator involved in various cellular processes, including cell proliferation and stress response mechanisms. By employing CRISPR-Cas9 or similar gene-editing technologies, these cell lines offer researchers a robust tool to study the biological functions of the BRAP gene and its implications in both health and disease.

The key functions of BRAP involve its role in modulating signaling pathways that are essential for cell survival, apoptosis, and the inflammatory response. When the BRAP gene is knocked out, it allows for the examination of the resultant phenotypic changes, enabling researchers to elucidate its contributions in oncogenesis, immune response, and other physiological processes. This mechanism of action provides a basis for understanding the potential roles of BRAP in various conditions, including cancer and autoimmune diseases.

The scientific importance of BRAP Gene Knockout Cell Lines lies in their applications across diverse research fields. They serve as invaluable models for drug screening, biomarker discovery, and therapeutic research, particularly in cancer biology where BRAP's regulatory influence on tumor progression is being comprehensively explored. In clinical settings, these cell lines can facilitate the validation of therapeutic targets, providing a platform for developing novel interventions.

One significant advantage of using BRAP Gene Knockout Cell Lines is their high specificity in targeting the BRAP gene without off-target effects, offering more reliable results compared to alternative methods, such as siRNA knockdown. Furthermore, the ability to produce isogenic cell lines through precise gene editing allows for controlled experimentation, enhancing reproducibility in research outcomes.

For researchers and clinicians, these cell lines provide a powerful asset in dissecting the multi-faceted roles of BRAP, paving the way for innovative research and potential clinical applications. By harnessing the insights gained from these models, users can contribute to advancing knowledge in cellular signaling and developing next-generation therapies.

Our company specializes in providing high-quality genetic models and tools tailored to the needs of the research community. With a commitment to scientific excellence and innovation, we strive to empower researchers in their quest to unravel the complexities of biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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