Gene: BMF
Official Full Name: Bcl2 modifying factorprovided by HGNC
Gene Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23748 | BMF Knockout cell line (HeLa) | Human | BMF | 1:3~1:6 | Negative | Online Inquiry |
KO23749 | BMF Knockout cell line (HEK293) | Human | BMF | 1:3~1:6 | Negative | Online Inquiry |
BMF Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the expression of the BMF (Bcl-2 modifying factor) gene. This gene plays a pivotal role in regulating apoptosis, influencing the balance between cell death and survival. By eliminating BMF, these knockout cell lines serve as a powerful tool for researchers investigating the mechanisms of apoptosis, cancer biology, and cellular responses to stress.
The primary function of BMF Gene Knockout Cell Lines lies in their ability to create a controlled environment for studying the pathways associated with cell survival and death. Researchers can utilize these cell lines to explore how the absence of BMF affects apoptotic signaling cascades and to identify potential compensatory mechanisms employed by the cell. This is particularly important in oncology, where understanding cell death resistance can lead to new therapeutic interventions.
The scientific significance of these knockout cell lines is immense, as they allow for the elucidation of BMF-related pathways and their implications in various diseases, particularly cancer. In clinical settings, insights gained from BMF research could inform the development of targeted therapies aimed at overcoming drug resistance in tumors.
One key advantage of using BMF Gene Knockout Cell Lines is the consistency and reliability they provide in experimental setups compared to using wild-type cell lines, which can exhibit variable responses. Furthermore, these knockout lines facilitate more precise investigations into the specific functional roles of the BMF gene, providing greater insights than alternatives like transient knockdown methods.
Researchers and clinicians benefit significantly from these knockout cell lines as they streamline the process for discovering new treatments and enhancing our understanding of cellular behavior in pathological contexts. Additionally, the stability of gene knockout lines ensures reproducible results across experiments, making them essential for both foundational research and translational work.
Our company specializes in providing high-quality, scientifically validated biological products, and our BMF Gene Knockout Cell Lines exemplify our commitment to advancing research and enhancing therapeutic discovery. Our expertise in gene editing technologies ensures that each product meets rigorous standards of performance and reliability, empowering researchers worldwide to unlock new biological insights.
Please note that all services are for research use only. Not intended for any clinical use.
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