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BCAN Knockout Cell Lines

Gene: BCAN

Official Full Name: brevicanprovided by HGNC

Gene Summary: This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19470 BCAN Knockout cell line (HEK293) Human BCAN 1:3~1:6 Negative Online Inquiry

Background

BCAN Gene Knockout Cell Lines are genetically engineered cell lines in which the BCAN gene has been selectively inactivated or "knocked out." The BCAN gene encodes for the brain-specific proteoglycan brevican, which plays a critical role in neural development and the maintenance of the extracellular matrix in the central nervous system. These cell lines serve as invaluable tools for studying the function of BCAN in neural processes, as well as in understanding various neurological conditions where BCAN is implicated.

The primary mechanism underlying the functionality of BCAN Gene Knockout Cell Lines lies in their ability to provide insights into the role of the BCAN protein. By examining these knockout cells, researchers can delve into the consequences of BCAN absence, such as altered neuronal growth, synaptogenesis, and cellular signaling pathways. This information is essential for deciphering the complex biology of brain disorders, including traumatic brain injury, neurodegenerative diseases, and developmental disorders.

In research and clinical settings, these cell lines are crucial for developing and testing therapeutics aimed at restoring normal brain function or mitigating the effects of diseases associated with aberrant BCAN expression. The knockout model allows for high-throughput screening of compounds that may influence BCAN-related pathways, facilitating the identification of potential drug candidates.

Compared to traditional models, BCAN Gene Knockout Cell Lines offer distinct advantages, including the ability to specifically target the functional impact of BCAN without confounding influences from other genes. This specificity enhances the accuracy of experimental outcomes, providing clear cause-and-effect relationships that are vital for advancing our understanding of brain biology.

For researchers and clinicians invested in neurological research and therapeutics, BCAN Gene Knockout Cell Lines represent a critical asset, enabling precision studies that could lead to groundbreaking discoveries. Our commitment to delivering high-quality biological products reflects our extensive expertise in genetic engineering and cell line development, ensuring that our clients have the tools necessary to advance their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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