Gene: B3GAT3
Official Full Name: beta-1,3-glucuronyltransferase 3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. A pseudogene of this gene has been identified on chromosome 3. [provided by RefSeq, Dec 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28212 | B3GAT3 Knockout cell line (HeLa) | Human | B3GAT3 | 1:3~1:6 | Negative | Online Inquiry |
KO28213 | B3GAT3 Knockout cell line (HCT 116) | Human | B3GAT3 | 1:2~1:4 | Negative | Online Inquiry |
KO28214 | B3GAT3 Knockout cell line (HEK293) | Human | B3GAT3 | 1:3~1:6 | Negative | Online Inquiry |
KO28215 | B3GAT3 Knockout cell line (A549) | Human | B3GAT3 | 1:3~1:4 | Negative | Online Inquiry |
B3GAT3 Gene Knockout Cell Lines are a specialized biological product designed for in-depth gene function studies and therapeutic development. These cell lines have been engineered to specifically disrupt the B3GAT3 gene, which encodes for a key enzyme involved in glycosaminoglycan biosynthesis. The knockout of this gene permits researchers to explore the role of B3GAT3 in various cellular processes, including cell signaling, extracellular matrix composition, and developmental biology.
The primary function of B3GAT3 gene knockout cell lines lies in their capacity to elucidate the biological pathways influenced by glucuronyl transfer, a process integral to the formation of heparan sulfate and other glycosaminoglycans. By providing a controlled environment where B3GAT3 is absent, scientists can effectively assess the downstream effects of this gene's loss, such as changes in cellular behavior, interactions with other biomolecules, and potential impacts on disease models, particularly in cancer and developmental disorders.
The scientific importance of B3GAT3 knockout cell lines is underscored by their applicability in both fundamental research and clinical settings. They offer a crucial tool for drug discovery and validation, allowing for the testing of pharmacological agents that target glycosaminoglycan synthesis pathways. Additionally, these cell lines facilitate the identification of novel therapeutic targets for conditions associated with altered glycosaminoglycan structures.
Compared to traditional gene-editing approaches, our B3GAT3 gene knockout cell lines provide a more reliable and reproducible model for studying gene function. The precision of the knockout ensures complete abrogation of target gene activity, minimizing off-target effects often encountered with other gene editing techniques. By using these cell lines, researchers can accelerate their studies, leading to expedited results and more meaningful insights into gene function.
For researchers and clinicians seeking innovative solutions in molecular biology and therapeutic interventions, our B3GAT3 gene knockout cell lines present a compelling choice. The ability to dissect complex biological mechanisms opens up new avenues for research and could lead to significant advancements in medical science.
Our company has established a reputation for excellence in developing cutting-edge biological products, fostering innovation and collaboration within the scientific community. We offer a diverse portfolio designed to empower researchers and clinicians in their quest for scientific discovery and therapeutic breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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