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ARR3 Knockout Cell Lines

Gene: ARR3

Official Full Name: arrestin 3provided by HGNC

Gene Summary: The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38919 ARR3 Knockout cell line (HEK293) Human ARR3 1:3~1:6 Negative Online Inquiry

Background

ARR3 Gene Knockout Cell Lines are a specialized set of genetically modified cell lines designed to facilitate the study of the retinal regulatory protein ARR3 (Arrestin-3). By employing advanced gene-editing techniques, these cell lines have been engineered to completely knock out the ARR3 gene, allowing researchers to investigate the protein's involvement in phototransduction and other cellular signaling pathways in a controlled environment.

The key function of the ARR3 Gene Knockout Cell Lines lies in their ability to elucidate the role of ARR3 in cellular response to light and in neurodegenerative processes associated with retinal diseases. The knockout mechanism effectively disables ARR3 protein synthesis, enabling comparative studies with wild-type cell lines. This allows for a clearer understanding of ARR3's cellular functions, interactions with other proteins, and its contribution to various pathological conditions.

Scientifically, the ARR3 Gene Knockout Cell Lines hold significant importance for both basic and applied research, especially in the fields of ophthalmology and neurology. They can be utilized to model retinal degenerative diseases, test potential therapeutic interventions, and conduct high-throughput drug screening, thereby contributing to the identification of novel treatment strategies.

Compared to alternative products, ARR3 Gene Knockout Cell Lines offer unparalleled specificity and control, allowing researchers to gather precise data on the effects of ARR3 deficiency. This enhanced experimental clarity reduces variability and enhances reproducibility, making them highly valuable in the research setting.

For researchers and clinicians, the ARR3 Gene Knockout Cell Lines represent a powerful tool for advancing our understanding of retinal health and disease mechanisms. They enable users to conduct experiments that would be challenging or impossible with traditional models, ultimately paving the way for breakthroughs in eye disease research and treatment.

With a commitment to advancing research through high-quality products, our company specializes in providing innovative biological tools that empower the scientific community in their pursuit of knowledge and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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