Gene: ARL1
Official Full Name: ARF like GTPase 1provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38937 | ARL1 Knockout cell line (HeLa) | Human | ARL1 | 1:3~1:6 | Negative | Online Inquiry |
KO38938 | ARL1 Knockout cell line (HCT 116) | Human | ARL1 | 1:2~1:4 | Negative | Online Inquiry |
KO38939 | ARL1 Knockout cell line (HEK293) | Human | ARL1 | 1:3~1:6 | Negative | Online Inquiry |
KO38940 | ARL1 Knockout cell line (A549) | Human | ARL1 | 1:3~1:4 | Negative | Online Inquiry |
ARL1 Gene Knockout Cell Lines are specially engineered cellular models developed to study the dysfunction and role of the ADP-ribosylation factor-like protein 1 (ARL1) in various physiological and pathological conditions. These cell lines have had the ARL1 gene inactivated, facilitating detailed investigations into its biological functions, interactions, and contributions to cellular processes such as membrane trafficking, organelle dynamics, and signal transduction pathways.
The primary mechanism of action of the ARL1 Gene Knockout Cell Lines lies in the elimination of ARL1's expression, allowing researchers to observe phenotypic changes and signaling disruptions caused by the absence of this key protein. By employing techniques such as immunofluorescence and functional assays, scientists can analyze how ARL1 influences processes like Golgi apparatus maintenance and protein transport, which are crucial for maintaining cellular homeostasis.
The scientific importance of ARL1 Gene Knockout Cell Lines extends into numerous research and clinical applications, particularly in the fields of cell biology, oncology, and neurobiology. Understanding the role of ARL1 can provide insights into cancer progression, neurodegenerative diseases, and other conditions where vesicular transport is affected. This knowledge can drive the development of targeted therapies and treatment strategies.
In comparison to traditional gene silencing techniques, the ARL1 Gene Knockout Cell Lines offer superior specificity and reliability, allowing for clearer delineation of ARL1's biological roles without off-target effects. Their use in high-throughput screening and drug discovery assays represents a significant advantage for researchers seeking innovative solutions in molecular therapeutics.
For researchers and clinicians dedicated to unraveling complex cellular processes, the ARL1 Gene Knockout Cell Lines present a valuable tool that bridges the gap between basic research and clinical application. Our company leverages extensive expertise in genetic engineering and cellular biology to produce high-quality biological products such as these knockout cell lines, ensuring that you have the best resources to advance your research.
Please note that all services are for research use only. Not intended for any clinical use.
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